Acute ethanol ingestion modifies the circulating plasma levels of atrial natriuretic peptide

Dennis A Wigle, Stephen C. Pang, Inder R. Sarda, John D. Watson, Nancy N. Radakovic, Rabindra Roy, T. Geoffrey Flynn

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Since ethanol ingestion is associated with a disruption of water and electrolyte balance in a variety of species, we sought to evaluate the regulatory control of atrial natriuretic peptide (ANP) in response to acute doses of ethanol. Male Sprague-Dawley rats were administered a 5-g/kg dose of ethanol (40% w/v) via a gastric tube, while control animals received an equivalent volume of water. Expressed as a percentage of control, plasma ANP levels were 39.0%, 28.5%, and 23.6% in the ethanol-treated animals at 30, 60, and 120 min postintubation, respectively. Ethanol-treated animals displayed blood alcohol concentrations of 89.0, 137.6, and 214.1 mg/dl at the same time periods. After 120 min, plasma renin activity was elevated from 8.7 to 20.3 ng/ml/h in conjunction with an increase in the levels of circulating aldosterone from 16.3 to 42.5 ng/dl and an increase in plasma vasopressin from 2.2 to 3.6 pg/ml. Levels of atrial ANP mRNA remained consistent over the time course of the experiment, and no changes in the amount of ventricular ANP transcript were observed. Tissue ANP levels were similar between ethanol-treated and water-loaded control animals. In vitro experiments using cultured cardiac myocytes suggest that ethanol exposure may not directly affect ANP secretion. We propose that acute ethanol treatment may inhibit atrial distension and subsequently modify the control of ANP release under volume loading conditions.

Original languageEnglish (US)
Pages (from-to)275-280
Number of pages6
JournalAlcohol
Volume10
Issue number4
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Atrial Natriuretic Factor
Ethanol
Eating
Plasmas
animal
Animals
water
experiment
Water
Water-Electrolyte Balance
alcohol
Aldosterone
Vasopressins
Renin
Cardiac Myocytes
Electrolytes
Sprague Dawley Rats
Rats
Stomach
Blood

Keywords

  • Alcohol
  • Aldosterone
  • ANP
  • Renin
  • Vasopressin

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Neuroscience(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

Wigle, D. A., Pang, S. C., Sarda, I. R., Watson, J. D., Radakovic, N. N., Roy, R., & Geoffrey Flynn, T. (1993). Acute ethanol ingestion modifies the circulating plasma levels of atrial natriuretic peptide. Alcohol, 10(4), 275-280. https://doi.org/10.1016/0741-8329(93)90005-9

Acute ethanol ingestion modifies the circulating plasma levels of atrial natriuretic peptide. / Wigle, Dennis A; Pang, Stephen C.; Sarda, Inder R.; Watson, John D.; Radakovic, Nancy N.; Roy, Rabindra; Geoffrey Flynn, T.

In: Alcohol, Vol. 10, No. 4, 1993, p. 275-280.

Research output: Contribution to journalArticle

Wigle, DA, Pang, SC, Sarda, IR, Watson, JD, Radakovic, NN, Roy, R & Geoffrey Flynn, T 1993, 'Acute ethanol ingestion modifies the circulating plasma levels of atrial natriuretic peptide', Alcohol, vol. 10, no. 4, pp. 275-280. https://doi.org/10.1016/0741-8329(93)90005-9
Wigle, Dennis A ; Pang, Stephen C. ; Sarda, Inder R. ; Watson, John D. ; Radakovic, Nancy N. ; Roy, Rabindra ; Geoffrey Flynn, T. / Acute ethanol ingestion modifies the circulating plasma levels of atrial natriuretic peptide. In: Alcohol. 1993 ; Vol. 10, No. 4. pp. 275-280.
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