Acute effects of delayed reperfusion following myocardial infarction: a 3D x-ray imaging analysis

Robert D. Simari, M. R. Bell, Y. C. Pao, B. J. Gersh, Erik L.M.D. Ritman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Clinical and experimental data suggest that delayed reperfusion of the infarct related artery may limit infarct expansion without increasing myocardial salvage. In order to assess the potential mechanisms involved, an acute closed chest canine model of myocardial infarction and delayed reperfusion was studied. Nineteen dogs underwent 3D computed tomography in the Dynamic Spatial Reconstructor (a fast, volume imaging, CT scanner) at baseline and three and four hours later to estimate left ventricular chamber volumes, global distensibility and regional myocardial stiffness. A control group was scanned without intervention. An occlusion group underwent four hours of coronary artery occlusion. A reperfusion group underwent three hours of coronary artery occlusion followed by one hour of reperfusion. Similar infarct sizes were seen in the occlusion and reperfusion groups. Globally reperfusion was associated with increased left ventricular end diastolic pressure and prolongation of global relaxation. Regionally reperfusion was associated with increased myocardial stiffness, intramyocardial blood volume and wall thickness within the infarct zone relative to the not reperfused myocardium.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsEric A. Hoffman
Pages383-392
Number of pages10
StatePublished - Jan 1 1996
EventMedical Imaging 1996: Physiology and Function from Multidimensional Images - Newport Beach, CA, USA
Duration: Feb 11 1996Feb 13 1996

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume2709
ISSN (Print)0277-786X

Other

OtherMedical Imaging 1996: Physiology and Function from Multidimensional Images
CityNewport Beach, CA, USA
Period2/11/962/13/96

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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  • Cite this

    Simari, R. D., Bell, M. R., Pao, Y. C., Gersh, B. J., & Ritman, E. L. M. D. (1996). Acute effects of delayed reperfusion following myocardial infarction: a 3D x-ray imaging analysis. In E. A. Hoffman (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (pp. 383-392). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2709).