Acute disseminated encephalomyelitis, transverse myelitis, and neuromyelitis optica

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Abstract

Purpose of Review: This review defines current clinical criteria for diagnosis, differential diagnosis, and clinical evaluation of acute disseminated encephalomyelitis, transverse myelitis, and neuromyelitis optica, and summarizes principles of treatment. Recent Findings: Consensus criteria for transverse myelitis and acute disseminated encephalomyelitis have been proposed. A specific biomarker, aquaporin-4 autoantibody, has been discovered for neuromyelitis optica that allows for early and accurate diagnosis even in the absence of cardinal findings of optic neuritis andmyelitis. The antibody is pathogenic and is facilitating an understanding of the pathophysiology of neuromyelitis optica and development of antigen-specific treatments. Summary: Clinical and radiologic findings combined with serologic findings may permit classification of syndromes of transverse myelitis and acute disseminated encephalomyelitis in ways that may predict risk of relapse, type of relapse, and prognosis. Treatment, especially to prevent relapse, is dependent on the specific disease context in which syndromes such as transverse myelitis occur.

Original languageEnglish (US)
Pages (from-to)944-967
Number of pages24
JournalCONTINUUM Lifelong Learning in Neurology
Volume19
Issue number4
DOIs
StatePublished - Aug 2013

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Transverse Myelitis
Acute Disseminated Encephalomyelitis
Neuromyelitis Optica
Recurrence
Aquaporin 4
Optic Neuritis
Autoantibodies
Early Diagnosis
Differential Diagnosis
Therapeutics
Biomarkers
Antigens
Antibodies

ASJC Scopus subject areas

  • Clinical Neurology
  • Genetics(clinical)

Cite this

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abstract = "Purpose of Review: This review defines current clinical criteria for diagnosis, differential diagnosis, and clinical evaluation of acute disseminated encephalomyelitis, transverse myelitis, and neuromyelitis optica, and summarizes principles of treatment. Recent Findings: Consensus criteria for transverse myelitis and acute disseminated encephalomyelitis have been proposed. A specific biomarker, aquaporin-4 autoantibody, has been discovered for neuromyelitis optica that allows for early and accurate diagnosis even in the absence of cardinal findings of optic neuritis andmyelitis. The antibody is pathogenic and is facilitating an understanding of the pathophysiology of neuromyelitis optica and development of antigen-specific treatments. Summary: Clinical and radiologic findings combined with serologic findings may permit classification of syndromes of transverse myelitis and acute disseminated encephalomyelitis in ways that may predict risk of relapse, type of relapse, and prognosis. Treatment, especially to prevent relapse, is dependent on the specific disease context in which syndromes such as transverse myelitis occur.",
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