Acute disseminated encephalomyelitis: Current understanding and controversies

Research output: Contribution to journalReview article

119 Scopus citations

Abstract

Acute disseminated encephalomyelitis (ADEM) is an uncommon monophasic idiopathic inflammatory demyelinating disease. Available diagnostic criteria do not reliably distinguish it from first presentations of relapsing diseases such as multiple sclerosis (MS) and neuromyelitis optica (NMO). In this article, we review current concepts about ADEM and what distinguishes it from other idiopathic inflammatory demyelinating disease, and we highlight controversial aspects and diagnostic problems. We review pathological differences between ADEM and MS in terms of their utility in the diagnosis of ADEM. Finally, we present a practical approach for management of patients suspected of having ADEM when the diagnosis is uncertain.

Original languageEnglish (US)
Pages (from-to)84-94
Number of pages11
JournalSeminars in Neurology
Volume28
Issue number1
DOIs
StatePublished - Feb 2008

Keywords

  • Acute disseminated encephalomyelitis
  • Idiopathic inflammatory demyelination disease
  • Perivenous encephalomyelitis
  • Postinfectious encephalomyelitis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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