TY - JOUR
T1 - Acute disseminated encephalomyelitis
T2 - Current understanding and controversies
AU - Young, Nathan P.
AU - Weinshenker, Brian G.
AU - Lucchinetti, Claudia F.
N1 - Funding Information:
We thank the National Health and Medical Research Council, Allen and Hanburys, and the Community Health and Anti-Tuberculosis Association for funding the 1990 study and we thank the Busselton Population Studies Group for their cooperation. We also thank the research assistants who collected the data. We are especially grateful to Mr John Dermand of the Department of Medicine, University of Sydney, and to Ms Elspeth Inglis of the Busselton Community Health Centre for their organisation skills in sampling and contacting the subjects.
PY - 2008/2
Y1 - 2008/2
N2 - Acute disseminated encephalomyelitis (ADEM) is an uncommon monophasic idiopathic inflammatory demyelinating disease. Available diagnostic criteria do not reliably distinguish it from first presentations of relapsing diseases such as multiple sclerosis (MS) and neuromyelitis optica (NMO). In this article, we review current concepts about ADEM and what distinguishes it from other idiopathic inflammatory demyelinating disease, and we highlight controversial aspects and diagnostic problems. We review pathological differences between ADEM and MS in terms of their utility in the diagnosis of ADEM. Finally, we present a practical approach for management of patients suspected of having ADEM when the diagnosis is uncertain.
AB - Acute disseminated encephalomyelitis (ADEM) is an uncommon monophasic idiopathic inflammatory demyelinating disease. Available diagnostic criteria do not reliably distinguish it from first presentations of relapsing diseases such as multiple sclerosis (MS) and neuromyelitis optica (NMO). In this article, we review current concepts about ADEM and what distinguishes it from other idiopathic inflammatory demyelinating disease, and we highlight controversial aspects and diagnostic problems. We review pathological differences between ADEM and MS in terms of their utility in the diagnosis of ADEM. Finally, we present a practical approach for management of patients suspected of having ADEM when the diagnosis is uncertain.
KW - Acute disseminated encephalomyelitis
KW - Idiopathic inflammatory demyelination disease
KW - Perivenous encephalomyelitis
KW - Postinfectious encephalomyelitis
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U2 - 10.1055/s-2007-1019130
DO - 10.1055/s-2007-1019130
M3 - Review article
C2 - 18256989
AN - SCOPUS:39449121111
SN - 0271-8235
VL - 28
SP - 84
EP - 94
JO - Seminars in Neurology
JF - Seminars in Neurology
IS - 1
ER -