Acute cholecystitis in an animal model: Findings on color Doppler sonography

F. T. Lee, D. R. DeLone, D. W. Bean, B. G. Broghammer, E. Mack, S. B. Perlman, J. W. Weiss

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

OBJECTIVE. The purpose of our study was to evaluate the color Doppler findings of acute cholecystitis in a controlled canine model. MATERIALS AND METHODS. Fourteen animals had a laparotomy: cystic duct ligation was done in eight, and incision with closure was performed in six control subjects. Animals were scanned in a blinded fashion preoperatively, immediately postoperatively, and on postoperative days 1-5. On postoperative day 5, a hepatobiliary scan was done with 2 mCi (74 MBq) 99mTc-mebrofenin. Blinded histopathology was performed and correlated with imaging. RESULTS. Flow was seen in the wall of each gallbladder at some point during the postoperative course, demonstrating vascular patency. Hepatobiliary scintigraphy confirmed cystic duct status in 12 cases; two animals died before radionuclide imaging was complete. Color Doppler signal decreased in the gallbladder wall in ligated dogs from postoperative day 1 to postoperative day 3 (p = .03 versus controls at postoperative day 2) and increasingly returned by postoperative day 5. Hyperemia was seen in only two cases (both with severe necrotizing cholecystitis) and only at postoperative day 5. Although not statistically significant, a weak trend of increasing flow with more severe pathologic grades of cholecystitis was observed (p = .20). CONCLUSIONS. In this animal model, loss of vascular signal (not hyperemia) at postoperative day 2 was the finding to diagnose early acute cholecystitis, although lack of flow can also be seen in some normal subjects. Flow tended to return by postoperative day 5, and it increased in some of the more severe cases of cholecystitis. Hyperemia was a somewhat useful sign of acute necrotizing cholecystitis.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalAmerican Journal of Roentgenology
Volume165
Issue number1
StatePublished - 1995
Externally publishedYes

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Doppler Color Ultrasonography
Acute Cholecystitis
Cholecystitis
Hyperemia
Cystic Duct
Animal Models
Gallbladder
Radionuclide Imaging
Vascular Patency
Color
Laparotomy
Ligation
Blood Vessels
Canidae
Dogs

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Lee, F. T., DeLone, D. R., Bean, D. W., Broghammer, B. G., Mack, E., Perlman, S. B., & Weiss, J. W. (1995). Acute cholecystitis in an animal model: Findings on color Doppler sonography. American Journal of Roentgenology, 165(1), 85-90.

Acute cholecystitis in an animal model : Findings on color Doppler sonography. / Lee, F. T.; DeLone, D. R.; Bean, D. W.; Broghammer, B. G.; Mack, E.; Perlman, S. B.; Weiss, J. W.

In: American Journal of Roentgenology, Vol. 165, No. 1, 1995, p. 85-90.

Research output: Contribution to journalArticle

Lee, FT, DeLone, DR, Bean, DW, Broghammer, BG, Mack, E, Perlman, SB & Weiss, JW 1995, 'Acute cholecystitis in an animal model: Findings on color Doppler sonography', American Journal of Roentgenology, vol. 165, no. 1, pp. 85-90.
Lee FT, DeLone DR, Bean DW, Broghammer BG, Mack E, Perlman SB et al. Acute cholecystitis in an animal model: Findings on color Doppler sonography. American Journal of Roentgenology. 1995;165(1):85-90.
Lee, F. T. ; DeLone, D. R. ; Bean, D. W. ; Broghammer, B. G. ; Mack, E. ; Perlman, S. B. ; Weiss, J. W. / Acute cholecystitis in an animal model : Findings on color Doppler sonography. In: American Journal of Roentgenology. 1995 ; Vol. 165, No. 1. pp. 85-90.
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