Acute Brain Diseases as Triggers for Stress Cardiomyopathy: Clinical Characteristics and Outcomes

Deena Nasr, Sara Tomasini, Abhiram Prasad, Alejandro Rabinstein

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: To determine the clinical characteristics and outcomes of patients with neurogenic stress cardiomyopathy (NSC) among patients admitted to our neuroscience intensive care unit (NICU). Methods: Following institutional review board approval, consecutive adult patients admitted to the NICU between 2009 and 2013 with definite and possible NSC were included. Data on patient demographics, baseline clinical information, cardiac function, and laboratory values were collected. Outcomes included length of stay, modified Rankin Scale (mRS) at discharge and long-term follow-up. Continuous variables were compared using a student’s t test, and categorical variables were compared using a Chi-square test. Results: Among 34 patients included in the study, the most common presenting symptom was dyspnea (17 patients, 50%). Subarachnoid hemorrhage (SAH) was the most common neurological inciting event (11 patients, 32.4%), but two-thirds of this cohort had other neurological triggers. The most common electrocardiogram changes were QT-interval prolongation (30 patients, 88.2%) and T-wave inversion (22 patients, 64.7%). The most common echocardiographic pattern was the apical variant (14 patients, 41.2%), and 26% of patients had right ventricular involvement (P = 0.03) which was a predictor of poor outcome along with inotropic support (P = 0.006). Functional outcome was poor (mRS > 3) in 53% of patients at discharge, but function improved over time in most survivors. Conclusions: NSC is most common after SAH, but can result from a wide spectrum of acute brain insults. Requirement of inotropic support was the strongest indicator of prognosis at last follow-up. Patients with NSC often have poor function at discharge but many improve over time.

Original languageEnglish (US)
Pages (from-to)356-361
Number of pages6
JournalNeurocritical Care
Volume27
Issue number3
DOIs
StatePublished - Dec 1 2017

Fingerprint

Takotsubo Cardiomyopathy
Brain Diseases
Acute Disease
Subarachnoid Hemorrhage
Neurosciences
Intensive Care Units
Patient Discharge
Research Ethics Committees
Patient Rights
Chi-Square Distribution
Dyspnea
Survivors
Length of Stay
Electrocardiography

Keywords

  • Apical ballooning syndrome
  • Neurogenic stress cardiomyopathy
  • Subarachnoid hemorrhage
  • Takotsubo cardiomyopathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine

Cite this

Acute Brain Diseases as Triggers for Stress Cardiomyopathy : Clinical Characteristics and Outcomes. / Nasr, Deena; Tomasini, Sara; Prasad, Abhiram; Rabinstein, Alejandro.

In: Neurocritical Care, Vol. 27, No. 3, 01.12.2017, p. 356-361.

Research output: Contribution to journalArticle

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