Acute and long-term effects of fluosol-DA 20% on respiratory system mechanics and diffusion capacity in dogs

Rolf D. Hubmayr, Joseph R. Rodarte

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We evaluated the acute and cumulative effects of Fluosol-DA 20% (Fluosol, Alpha Therapeutics, Los Angeles) on respiratory system mechanics and the diffusing capacity for carbon monoxide (DLCO) in six dogs. A total dose of 45 to 75 mL/kg was administered during a period of eight to 12 days. After a loading dose of 15 mL/kg was a dose of 10 mL/kg was administered intravenously on alternate study days in four dogs and on successive days in two dogs. There were no significant differences between the initial and final study day in total lung capacity (TLC), residual volume (RV), static lung compliance (CSTAT), dynamic lung compliance (CDYN), the retractive force at 50% at TLC (P50 TLC), and the diffusion capacity for carbon monoxide (CLCO). Although there was a small increase in the total pulmonary resistance (RTP, 0.8 to 1.8 cm H2O/L/s; P < .05), its absolute value remained in the normal range. In contrast to the lack of chronic dose-dependent and time-dependent changes in lung mechanics and DLCO, there was a transient decrease in CDYN, from 0.066 to 0.047 L/cm H2O, and an increase in RTP, from 1.44 to 4.83 cm H2O/L/s (P < .001), immediately following the infusion of Fluosol. We conclude that an increase in pulmonary resistance to airflow is part of the idiosyncratic acute reaction after the administration of Fluosol, while the repeated administration of Fluosol has little effect on pulmonary gas transfer assessed by CLCO and respiratory system mechanics.

Original languageEnglish (US)
Pages (from-to)232-239
Number of pages8
JournalJournal of Critical Care
Volume3
Issue number4
DOIs
StatePublished - 1988

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Respiratory Mechanics
Total Lung Capacity
Respiratory System
Dogs
Lung Compliance
Lung
Carbon Monoxide
Residual Volume
Los Angeles
Mechanics
Reference Values
Gases
glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination
fluosol

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Acute and long-term effects of fluosol-DA 20% on respiratory system mechanics and diffusion capacity in dogs. / Hubmayr, Rolf D.; Rodarte, Joseph R.

In: Journal of Critical Care, Vol. 3, No. 4, 1988, p. 232-239.

Research output: Contribution to journalArticle

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