Acute airway compromise after recombinant human TSH administration: A case report and review of the literature

Eric Dowling; Jan Kasperbauer; John Morris; Semirra Bayan

doi:10.1002/lary.28439

Acute airway compromise after recombinant human TSH administration: A case report and review of the literature

Eric Dowling, Jan Kasperbauer, John Morris, Semirra Bayan

Department of Otorhinolaryngology ENT

Research output: Contribution to journal › Article › peer-review

Abstract

Radioiodine ablation is a commonly utilized treatment for differentiated thyroid carcinoma. Uptake of radioiodine can be enhanced by pretreatment with thyroid hormone withdrawal or administration of recombinant human thyroid-stimulating hormone (rhTSH). rhTSH is generally well-tolerated with minimal adverse effects. However, in patients with extensive tumor burden in confined anatomic spaces, rapid enlargement of normal or neoplastic thyroid tissue secondary to rhTSH administration can result in significant compressive effects. In this report, we describe a case of rapid airway deterioration requiring intubation in a patient with involvement of the thyroid cartilage by papillary thyroid carcinoma. Laryngoscope, 122:0000–0000, 2019 Laryngoscope, 130:2725–2727, 2020.

Original language	English (US)
Pages (from-to)	2725-2727
Number of pages	3
Journal	Laryngoscope
Volume	130
Issue number	11
DOIs	https://doi.org/10.1002/lary.28439
State	Published - Nov 1 2020

Keywords

Thyroid cancer
airway
laryngoplasty
rhTSH

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/lary.28439

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title = "Acute airway compromise after recombinant human TSH administration: A case report and review of the literature",

abstract = "Radioiodine ablation is a commonly utilized treatment for differentiated thyroid carcinoma. Uptake of radioiodine can be enhanced by pretreatment with thyroid hormone withdrawal or administration of recombinant human thyroid-stimulating hormone (rhTSH). rhTSH is generally well-tolerated with minimal adverse effects. However, in patients with extensive tumor burden in confined anatomic spaces, rapid enlargement of normal or neoplastic thyroid tissue secondary to rhTSH administration can result in significant compressive effects. In this report, we describe a case of rapid airway deterioration requiring intubation in a patient with involvement of the thyroid cartilage by papillary thyroid carcinoma. Laryngoscope, 122:0000–0000, 2019 Laryngoscope, 130:2725–2727, 2020.",

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Acute airway compromise after recombinant human TSH administration: A case report and review of the literature

Abstract

Keywords

ASJC Scopus subject areas

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