Abstract
Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5-8 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 347 |
| Issue number | 1 |
| DOIs | |
| State | Published - Aug 14 2003 |
| Externally published | Yes |
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Keywords
- Acupuncture
- c-Fos
- Caspase-3
- Ischemic gerbils
- Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining
- Zusanli acupoint
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils. / Jang, Mi-Hyeon D; Shin, Min Chul; Lee, Taeck Hyun; Lim, Baek Vin; Shin, Mal Soon; Min, Byung Il; Kim, Hong; Cho, Sonhae; Kim, Ee Hwa; Kim, Chang Ju.
In: Neuroscience Letters, Vol. 347, No. 1, 14.08.2003, p. 5-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils
AU - Jang, Mi-Hyeon D
AU - Shin, Min Chul
AU - Lee, Taeck Hyun
AU - Lim, Baek Vin
AU - Shin, Mal Soon
AU - Min, Byung Il
AU - Kim, Hong
AU - Cho, Sonhae
AU - Kim, Ee Hwa
AU - Kim, Chang Ju
PY - 2003/8/14
Y1 - 2003/8/14
N2 - Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.
AB - Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.
KW - Acupuncture
KW - c-Fos
KW - Caspase-3
KW - Ischemic gerbils
KW - Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining
KW - Zusanli acupoint
UR - http://www.scopus.com/inward/record.url?scp=0038642510&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038642510&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(03)00512-3
DO - 10.1016/S0304-3940(03)00512-3
M3 - Article
C2 - 12865128
AN - SCOPUS:0038642510
VL - 347
SP - 5
EP - 8
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 1
ER -