Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils

Mi-Hyeon D Jang; Min Chul Shin; Taeck Hyun Lee; Baek Vin Lim; Mal Soon Shin; Byung Il Min; Hong Kim; Sonhae Cho; Ee Hwa Kim; Chang Ju Kim

doi:10.1016/S0304-3940(03)00512-3

Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils

Mi-Hyeon D Jang, Min Chul Shin, Taeck Hyun Lee, Baek Vin Lim, Mal Soon Shin, Byung Il Min, Hong Kim, Sonhae Cho, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journal › Article

37 Scopus citations

Abstract

Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.

Original language	English (US)
Pages (from-to)	5-8
Number of pages	4
Journal	Neuroscience Letters
Volume	347
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(03)00512-3
State	Published - Aug 14 2003
Externally published	Yes

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Keywords

Acupuncture
c-Fos
Caspase-3
Ischemic gerbils
Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining
Zusanli acupoint

ASJC Scopus subject areas

Neuroscience(all)

Cite this

Jang, M-H. D., Shin, M. C., Lee, T. H., Lim, B. V., Shin, M. S., Min, B. I., Kim, H., Cho, S., Kim, E. H., & Kim, C. J. (2003). Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils. Neuroscience Letters, 347(1), 5-8. https://doi.org/10.1016/S0304-3940(03)00512-3

Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils. / Jang, Mi-Hyeon D; Shin, Min Chul; Lee, Taeck Hyun; Lim, Baek Vin; Shin, Mal Soon; Min, Byung Il; Kim, Hong; Cho, Sonhae; Kim, Ee Hwa; Kim, Chang Ju.

In: Neuroscience Letters, Vol. 347, No. 1, 14.08.2003, p. 5-8.

Research output: Contribution to journal › Article

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abstract = "Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.",

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10.1016/S0304-3940(03)00512-3