Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils

Mi Hyeon Jang, Min Chul Shin, Taeck Hyun Lee, Baek Vin Lim, Mal Soon Shin, Byung Il Min, Hong Kim, Sonhae Cho, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.

Original languageEnglish (US)
Pages (from-to)5-8
Number of pages4
JournalNeuroscience Letters
Volume347
Issue number1
DOIs
StatePublished - Aug 14 2003

Keywords

  • Acupuncture
  • Caspase-3
  • Ischemic gerbils
  • Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining
  • Zusanli acupoint
  • c-Fos

ASJC Scopus subject areas

  • Neuroscience(all)

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