Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils

Mi Hyeon Jang; Min Chul Shin; Taeck Hyun Lee; Baek Vin Lim; Mal Soon Shin; Byung Il Min; Hong Kim; Sonhae Cho; Ee Hwa Kim; Chang Ju Kim

doi:10.1016/S0304-3940(03)00512-3

Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils

Mi Hyeon Jang, Min Chul Shin, Taeck Hyun Lee, Baek Vin Lim, Mal Soon Shin, Byung Il Min, Hong Kim, Sonhae Cho, Ee Hwa Kim, Chang Ju Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.

Original language	English (US)
Pages (from-to)	5-8
Number of pages	4
Journal	Neuroscience Letters
Volume	347
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(03)00512-3
State	Published - Aug 14 2003

Keywords

Acupuncture
Caspase-3
Ischemic gerbils
Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining
Zusanli acupoint
c-Fos

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(03)00512-3

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title = "Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils",

abstract = "Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.",

keywords = "Acupuncture, Caspase-3, Ischemic gerbils, Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining, Zusanli acupoint, c-Fos",

author = "Jang, {Mi Hyeon} and Shin, {Min Chul} and Lee, {Taeck Hyun} and Lim, {Baek Vin} and Shin, {Mal Soon} and Min, {Byung Il} and Hong Kim and Sonhae Cho and Kim, {Ee Hwa} and Kim, {Chang Ju}",

note = "Funding Information: This study was supported by a grant of the Oriental Medicine R&D Project, Ministry of Health & Welfare, Republic of Korea (HMP-02-PJ9-PG3-20600-0007).",

year = "2003",

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doi = "10.1016/S0304-3940(03)00512-3",

language = "English (US)",

volume = "347",

pages = "5--8",

journal = "Neuroscience Letters",

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TY - JOUR

T1 - Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils

AU - Jang, Mi Hyeon

AU - Shin, Min Chul

AU - Lee, Taeck Hyun

AU - Lim, Baek Vin

AU - Shin, Mal Soon

AU - Min, Byung Il

AU - Kim, Hong

AU - Cho, Sonhae

AU - Kim, Ee Hwa

AU - Kim, Chang Ju

N1 - Funding Information: This study was supported by a grant of the Oriental Medicine R&D Project, Ministry of Health & Welfare, Republic of Korea (HMP-02-PJ9-PG3-20600-0007).

PY - 2003/8/14

Y1 - 2003/8/14

N2 - Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.

AB - Acupuncture has been used for the enhancement of functional recovery from various disorders including stroke. In the present study, the effects of acupuncture on the c-Fos expression and apoptosis in the hippocampal CA1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-Fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay. Enhanced Fos, TUNEL, and caspase-3 positivities were detected in the hippocampal CA1 region in the ischemic gerbils. Acupunctural treatment suppressed the ischemia-induced increment in the number of Fos-, TUNEL-, and caspase-3-positive cells: the most potent suppressive effect was observed at the Zusanli acupoint. These results suggest that acupunctural treatment alleviates ischemia-induced apoptosis and may aid in the recovery following ischemic cerebral injury.

KW - Acupuncture

KW - Caspase-3

KW - Ischemic gerbils

KW - Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining

KW - Zusanli acupoint

KW - c-Fos

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Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils

Abstract

Keywords

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