Acupuncture modulates expressions of nitric oxide synthase and c-Fos in hippocampus after transient global ischemia in gerbils

Ji Eun Kang, Hye Jung Lee, Sabina Lim, Ee Hwa Kim, Tae Hee Lee, Mi Hyeon Jang, Min Chul Shin, Baek Vin Lim, Youn Jung Kim, Chang Ju Kim

Research output: Contribution to journalArticle


The effects of acupuncture on the expressions of nitric oxide synthase (NOS) and c-Fos in the hippocampus of gerbils after transient ischemia were investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry and Fos immunohistochemistry. In animals of the ischemia-induction groups, both common carotid arteries were occluded for 5 minutes. Animals of the acupunctued groups were given acupunctural treatment at Zusanli twice daily for 9 consecutive days. Acupuncture was shown to decrease NADPH-d and c-Fos levels in both the sham-operation group and the ischemia-induction group. These results suggest that acupuncture modulates the expressions of NOS and c-Fos in the hippocampus.

Original languageEnglish (US)
Pages (from-to)581-590
Number of pages10
JournalAmerican Journal of Chinese Medicine
Issue number4
StatePublished - Dec 1 2003



  • Acupuncture
  • Hippocampus
  • Nitric Oxide Synthase
  • Zusanli Acupoint
  • c-Fos

ASJC Scopus subject areas

  • Complementary and alternative medicine

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