Acupuncture increases nitric oxide synthase expression in hippocampus of streptozotocin-induced diabetic rats

Mi Hyeon Jang, Min Chul Shin, Baek Vin Lim, Hyun Bae Kim, Young Pyo Kim, Ee Hwa Kim, Hong Kim, Mal Soon Shin, Sung Soo Kim, Chang Ju Kim

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

In the present study, the effect of acupuncture at Zusanli acupoint on nitric oxide synthase (NOS) expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Animals were divided into four groups: the control group, the nondiabetic and acupunctured group, the STZ-induced diabetes group, and the STZ-induced diabetes and acupunctured group. From the results, NADPH-d-positive neurons in the hippocampus were decreased in STZ-induced diabetic rats, while acupuncture increased NOS expression significantly under diabetic conditions. In the present study, it can be suggested that acupuncture treatment may modulate NOS activity in the hippocampus under diabetic conditions.

Original languageEnglish (US)
Pages (from-to)305-313
Number of pages9
JournalAmerican Journal of Chinese Medicine
Volume31
Issue number2
DOIs
StatePublished - Dec 1 2003

Keywords

  • Acupuncture
  • Nicotinamide Adenine Dinucleotide Phosphate-diaphorase Histochemistry
  • Nitric Oxide Synthase
  • Streptozotocin
  • Zusanli Acupoint

ASJC Scopus subject areas

  • Complementary and alternative medicine

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    Jang, M. H., Shin, M. C., Lim, B. V., Kim, H. B., Kim, Y. P., Kim, E. H., Kim, H., Shin, M. S., Kim, S. S., & Kim, C. J. (2003). Acupuncture increases nitric oxide synthase expression in hippocampus of streptozotocin-induced diabetic rats. American Journal of Chinese Medicine, 31(2), 305-313. https://doi.org/10.1142/S0192415X03000989