Acupuncture increases nitric oxide synthase expression in hippocampus of streptozotocin-induced diabetic rats

Mi-Hyeon D Jang, Min Chul Shin, Baek Vin Lim, Hyun Bae Kim, Young Pyo Kim, Ee Hwa Kim, Hong Kim, Mal Soon Shin, Sung Soo Kim, Chang Ju Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In the present study, the effect of acupuncture at Zusanli acupoint on nitric oxide synthase (NOS) expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) histochemistry. Animals were divided into four groups: the control group, the nondiabetic and acupunctured group, the STZ-induced diabetes group, and the STZ-induced diabetes and acupunctured group. From the results, NADPH-d-positive neurons in the hippocampus were decreased in STZ-induced diabetic rats, while acupuncture increased NOS expression significantly under diabetic conditions. In the present study, it can be suggested that acupuncture treatment may modulate NOS activity in the hippocampus under diabetic conditions.

Original languageEnglish (US)
Pages (from-to)305-313
Number of pages9
JournalAmerican Journal of Chinese Medicine
Volume31
Issue number2
DOIs
StatePublished - 2003
Externally publishedYes

Fingerprint

Acupuncture
Streptozocin
Nitric Oxide Synthase
Hippocampus
Experimental Diabetes Mellitus
NADP
Acupuncture Therapy
Acupuncture Points
Neurons
Control Groups

Keywords

  • Acupuncture
  • Nicotinamide Adenine Dinucleotide Phosphate-diaphorase Histochemistry
  • Nitric Oxide Synthase
  • Streptozotocin
  • Zusanli Acupoint

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Acupuncture increases nitric oxide synthase expression in hippocampus of streptozotocin-induced diabetic rats. / Jang, Mi-Hyeon D; Shin, Min Chul; Lim, Baek Vin; Kim, Hyun Bae; Kim, Young Pyo; Kim, Ee Hwa; Kim, Hong; Shin, Mal Soon; Kim, Sung Soo; Kim, Chang Ju.

In: American Journal of Chinese Medicine, Vol. 31, No. 2, 2003, p. 305-313.

Research output: Contribution to journalArticle

Jang, Mi-Hyeon D ; Shin, Min Chul ; Lim, Baek Vin ; Kim, Hyun Bae ; Kim, Young Pyo ; Kim, Ee Hwa ; Kim, Hong ; Shin, Mal Soon ; Kim, Sung Soo ; Kim, Chang Ju. / Acupuncture increases nitric oxide synthase expression in hippocampus of streptozotocin-induced diabetic rats. In: American Journal of Chinese Medicine. 2003 ; Vol. 31, No. 2. pp. 305-313.
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