Acupuncture decreases nitric oxide synthase expression in periaqueductal gray area of rats with streptozotocin-induced diabetes

Mi Hyeon Jang, Min Chul Shin, Gyo Sung Koo, Choong Yeol Lee, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Acupuncture has been used as a clinical treatment in Oriental medicine for various diseases including diabetes mellitus, one of the most common metabolic disorders in humans. In the present study, the effect of acupuncture on the expressions of neuronal nitric oxide synthase (nNOS) and nitric oxide synthase (NOS) in the dorsolateral periaqueductal gray (DL-PAG) area of rats with streptozotocin (STZ)-induced diabetes was investigated via nNOS immunohistochemistry and nicotinamide adenine dinucleotide phosphate-diaphorase histochemistry. Enhanced expression of nNOS and NOS was detected in the DL-PAG of rats with STZ-induced diabetes, and acupunctural treatment at Zusanli acupoint suppressed the diabetes-induced enhancement in the expression of nNOS and NOS. The present results demonstrate that acupuncture is effective in the modulation of the expression of nNOS and NOS in the DL-PAG under diabetic conditions.

Original languageEnglish (US)
Pages (from-to)155-158
Number of pages4
JournalNeuroscience Letters
Volume337
Issue number3
DOIs
StatePublished - Feb 13 2003

Keywords

  • Acupuncture
  • Diabetes
  • Dorsolateral periaqueductal gray
  • Neuronal nitric oxide synthase
  • Nitric oxide synthase

ASJC Scopus subject areas

  • Neuroscience(all)

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