Acupuncture decreases neuropeptide y expression in the hypothalamus of rats with streptozotocin-induced diabetes

Jae Dong Lee, Mi-Hyeon D Jang, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

It has been known that acupuncture has various effects such as analgesia, promotion of homeostasis, improvements in brain circulation, and rectification of internal disorders. Neuropeptide Y (NPY), a 36-amino-acid peptide, is known to increase appetite. In the present study, the effect of acupuncture stimulation at Zusanli (St.36) on NPY expression in the Streptozotocin (STZ)-induced diabetic rats was investigated via immunohistochemistry. Increased NPY expression was detected in both the Arcuate nucleus (ARN) and the Paraventricular nucleus (PVN) of the Hypothalamus in rats with in STZ-induced diabetes. Needling on Zusanli resulted in decreased NPY levels in both the ARN and PVN of diabetic rats. The present study shows that acupuncture suppressed NPY expression in the ARN and PVN of the Hypothalamus in STZ-induced diabetic rats, suggesting the possibility that acupuncture treatment is effective in curbing the hyperphagia of diabetes.

Original languageEnglish (US)
Pages (from-to)73-82
Number of pages10
JournalAcupuncture and Electro-Therapeutics Research
Volume29
Issue number1-2
StatePublished - 2004
Externally publishedYes

Fingerprint

Experimental Diabetes Mellitus
Neuropeptide Y
Acupuncture
Neuropeptides
Hypothalamus
Arcuate Nucleus of Hypothalamus
Paraventricular Hypothalamic Nucleus
Streptozocin
Acupuncture Therapy
Hyperphagia
Appetite
Analgesia
Homeostasis
Immunohistochemistry
Amino Acids
Peptides
Brain

Keywords

  • Acupuncture
  • Diabetes
  • Hyperphagia
  • Hypothalamus
  • Immunohistochemistry
  • Neuropeptide Y
  • Streptozotocin

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Neuroscience(all)
  • Complementary and alternative medicine

Cite this

Acupuncture decreases neuropeptide y expression in the hypothalamus of rats with streptozotocin-induced diabetes. / Lee, Jae Dong; Jang, Mi-Hyeon D; Kim, Ee Hwa; Kim, Chang Ju.

In: Acupuncture and Electro-Therapeutics Research, Vol. 29, No. 1-2, 2004, p. 73-82.

Research output: Contribution to journalArticle

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