Acupuncture decreases neuropeptide y expression in the hypothalamus of rats with streptozotocin-induced diabetes

Jae Dong Lee, Mi Hyeon Jang, Ee Hwa Kim, Chang Ju Kim

Research output: Contribution to journalArticle

13 Scopus citations


It has been known that acupuncture has various effects such as analgesia, promotion of homeostasis, improvements in brain circulation, and rectification of internal disorders. Neuropeptide Y (NPY), a 36-amino-acid peptide, is known to increase appetite. In the present study, the effect of acupuncture stimulation at Zusanli (St.36) on NPY expression in the Streptozotocin (STZ)-induced diabetic rats was investigated via immunohistochemistry. Increased NPY expression was detected in both the Arcuate nucleus (ARN) and the Paraventricular nucleus (PVN) of the Hypothalamus in rats with in STZ-induced diabetes. Needling on Zusanli resulted in decreased NPY levels in both the ARN and PVN of diabetic rats. The present study shows that acupuncture suppressed NPY expression in the ARN and PVN of the Hypothalamus in STZ-induced diabetic rats, suggesting the possibility that acupuncture treatment is effective in curbing the hyperphagia of diabetes.

Original languageEnglish (US)
Pages (from-to)73-82
Number of pages10
JournalAcupuncture and Electro-Therapeutics Research
Issue number1-2
StatePublished - Jan 1 2004



  • Acupuncture
  • Diabetes
  • Hyperphagia
  • Hypothalamus
  • Immunohistochemistry
  • Neuropeptide Y
  • Streptozotocin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Complementary and alternative medicine
  • Anesthesiology and Pain Medicine

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