TY - JOUR
T1 - Activity of Omadacycline in Rat Methicillin-Resistant Staphylococcus aureus Osteomyelitis
AU - Karau, Melissa J.
AU - Schmidt-Malan, Suzannah M.
AU - Cunningham, Scott A.
AU - Mandrekar, Jayawant N.
AU - Pritt, Bobbi S.
AU - Keepers, Tiffany R.
AU - Serio, Alisa W.
AU - Chitra, Surya
AU - Patel, Robin
N1 - Publisher Copyright:
© 2022 Karau et al.
PY - 2022/1
Y1 - 2022/1
N2 - Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. All treatment groups had less MRSA recovered than salinetreated animals. The emergence of rifampin resistance was observed in 3 of 16 animals with rifampin monotherapy and none with rifampin combination therapy. After treatment, the median tibial bacterial loads were 6.04, 0.1, 4.81, and 5.24 log10 CFU/g for saline-, rifampin-, vancomycin-, and omadacycline-treated animals, respectively. Omadacycline or vancomycin administered with rifampin yielded no detectable MRSA. Omadacycline administered with rifampin deserves evaluation in humans as a potential treatment for osteomyelitis.
AB - Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of methicillin-resistant Staphylococcus aureus (MRSA) osteomyelitis. All treatment groups had less MRSA recovered than salinetreated animals. The emergence of rifampin resistance was observed in 3 of 16 animals with rifampin monotherapy and none with rifampin combination therapy. After treatment, the median tibial bacterial loads were 6.04, 0.1, 4.81, and 5.24 log10 CFU/g for saline-, rifampin-, vancomycin-, and omadacycline-treated animals, respectively. Omadacycline or vancomycin administered with rifampin yielded no detectable MRSA. Omadacycline administered with rifampin deserves evaluation in humans as a potential treatment for osteomyelitis.
KW - Methicillin-resistant Staphylococcus aureus
KW - Omadacycline
KW - Osteomyelitis
KW - Rifampin
KW - Vancomycin
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U2 - 10.1128/AAC.01703-21
DO - 10.1128/AAC.01703-21
M3 - Article
C2 - 34723626
AN - SCOPUS:85123120286
SN - 0066-4804
VL - 66
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 1
M1 - e01703-21
ER -