TY - JOUR
T1 - Activity of fixed direct electrical current in experimental Staphylococcus aureus foreign-body osteomyelitis
AU - Schmidt-Malan, Suzannah M.
AU - Brinkman, Cassandra L.
AU - Greenwood-Quaintance, Kerryl E.
AU - Karau, Melissa J.
AU - Mandrekar, Jayawant N.
AU - Patel, Robin
N1 - Funding Information:
Research reported in this publication was supported by the National Institute of Allergy and Infectious Diseases under Award Number R01 AI091594 . RP is also supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number R01 AR056647 . CB was supported under the National Institute of Arthritis and Musculoskeletal and Skin Diseases for the Musculoskeletal Research Training Program under award number T32 AR56950 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/2
Y1 - 2019/2
N2 - Fixed DC was compared to ceftriaxone, ceftriaxone with 200 μA fixed DC, or no treatment in a rat model of methicillin-susceptible Staphylococcus aureus foreign-body osteomyelitis. After 3 weeks, fewer bacteria were present in bones of the ceftriaxone group (5.71 log 10 cfu/g [P = 0.0004]) and the ceftriaxone/DC group (3.53 log 10 cfu/g [P = 0.0002]) than untreated controls (6.70 log 10 cfu/g). Fewer bacteria were present in the ceftriaxone/DC group than in the ceftriaxone-alone and DC-alone groups (P = 0.0012 and 0.0008, respectively). There were also fewer bacteria on the implanted wires in the groups treated with ceftriaxone (5.47 log 10 cfu/cm 2 ) or ceftriaxone/DC (2.82 log 10 cfu/cm 2 ) than in the untreated controls (6.44 log 10 cfu/cm 2 [P = 0.0003 and 0.0002, respectively]). There were fewer bacteria in the ceftriaxone/DC rats than in the ceftriaxone-alone– and fixed DC-alone–treated rats (P = 0.0017 and 0.0016, respectively). Fixed DC with an antibiotic may be useful for treating foreign-body infections caused by S. aureus.
AB - Fixed DC was compared to ceftriaxone, ceftriaxone with 200 μA fixed DC, or no treatment in a rat model of methicillin-susceptible Staphylococcus aureus foreign-body osteomyelitis. After 3 weeks, fewer bacteria were present in bones of the ceftriaxone group (5.71 log 10 cfu/g [P = 0.0004]) and the ceftriaxone/DC group (3.53 log 10 cfu/g [P = 0.0002]) than untreated controls (6.70 log 10 cfu/g). Fewer bacteria were present in the ceftriaxone/DC group than in the ceftriaxone-alone and DC-alone groups (P = 0.0012 and 0.0008, respectively). There were also fewer bacteria on the implanted wires in the groups treated with ceftriaxone (5.47 log 10 cfu/cm 2 ) or ceftriaxone/DC (2.82 log 10 cfu/cm 2 ) than in the untreated controls (6.44 log 10 cfu/cm 2 [P = 0.0003 and 0.0002, respectively]). There were fewer bacteria in the ceftriaxone/DC rats than in the ceftriaxone-alone– and fixed DC-alone–treated rats (P = 0.0017 and 0.0016, respectively). Fixed DC with an antibiotic may be useful for treating foreign-body infections caused by S. aureus.
KW - Prosthetic joint infection
KW - Staphylococcus aureus
KW - Treatment
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U2 - 10.1016/j.diagmicrobio.2018.09.006
DO - 10.1016/j.diagmicrobio.2018.09.006
M3 - Article
C2 - 30293677
AN - SCOPUS:85054352604
SN - 0732-8893
VL - 93
SP - 92
EP - 95
JO - Diagnostic Microbiology and Infectious Disease
JF - Diagnostic Microbiology and Infectious Disease
IS - 2
ER -