TY - JOUR
T1 - Activity of biodegradable polymeric nanosponges against dual-species bacterial biofilms
AU - Nabawy, Ahmed
AU - Makabenta, Jessa Marie
AU - Li, Cheng Hsuan
AU - Park, Jungmi
AU - Chattopadhyay, Aritra Nath
AU - Schmidt-Malan, Suzannah
AU - Gupta, Akash
AU - Patel, Robin
AU - Rotello, Vincent M.
N1 - Publisher Copyright:
© 2020 American Chemical Society
PY - 2021/5/10
Y1 - 2021/5/10
N2 - Infections caused by multidrug-resistant (MDR) bacteria present an emerging global health crisis, and the threat is intensified by the involvement of biofilms. Some biofilm infections involve more than one species; this can further challenge treatment using traditional antibiotics. Nanomaterials are being developed as alternative therapeutics to traditional antibiotics; here we report biodegradable polymer-stabilized oil-in-water nanosponges (BNS) and show their activity against dual-species bacterial biofilms. The described engineered nanosponges demonstrated broad-spectrum antimicrobial activity through prevention of dual-species biofilm formation as well as eradication of preformed biofilms. The BNS showed no toxicity against mammalian cells. Together, these data highlight the therapeutic potential of this platform.
AB - Infections caused by multidrug-resistant (MDR) bacteria present an emerging global health crisis, and the threat is intensified by the involvement of biofilms. Some biofilm infections involve more than one species; this can further challenge treatment using traditional antibiotics. Nanomaterials are being developed as alternative therapeutics to traditional antibiotics; here we report biodegradable polymer-stabilized oil-in-water nanosponges (BNS) and show their activity against dual-species bacterial biofilms. The described engineered nanosponges demonstrated broad-spectrum antimicrobial activity through prevention of dual-species biofilm formation as well as eradication of preformed biofilms. The BNS showed no toxicity against mammalian cells. Together, these data highlight the therapeutic potential of this platform.
KW - Antimicrobials
KW - Dual-species biofilms
KW - Multidrug resistance
KW - Nanosponges
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UR - http://www.scopus.com/inward/citedby.url?scp=85097785299&partnerID=8YFLogxK
U2 - 10.1021/acsbiomaterials.0c01433
DO - 10.1021/acsbiomaterials.0c01433
M3 - Article
C2 - 33966379
AN - SCOPUS:85097785299
SN - 2373-9878
VL - 7
SP - 1780
EP - 1786
JO - ACS Biomaterials Science and Engineering
JF - ACS Biomaterials Science and Engineering
IS - 5
ER -