The Mayo Clinic biomechanics laboratory was established in 1972 within the Department of Orthopedics. In the past fourteen years, the primary functions and activities of the laboratory have been to conduct research and provide service related to biomechanics of the musculoskeletal system. In addition, the laboratory has participated in multiple collaborative projects with other departments and medical specialities. In this presentation, the activities involving project design, analytic and experimental methods, results, and the applications generated will be briefly reviewed. More specific details of each activity can be obtained from the key references included here. 66 refs.