Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis

R. Goldbach-Mansky, J. M. Lee, J. M. Hoxworth, D. Smith, P. Duray, H. R. Schumacher, C. H. Yarboro, J. Klippel, D. Kleiner, H. S. El-Gabalawy, P. Duray, D. Kleiner

Research output: Contribution to journalArticle

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Abstract

Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients. Immunohistological staining of MMP-2, MMP-14 and TIMP-2 localized to corresponding areas in the synovial lining layer and was almost absent in normal synovium. Patients with radiographic erosions had significantly higher levels of active MMP-2 than patients with no erosions, suggesting that activated MMP-2 levels in synovial tissue may be a marker for a more aggressive synovial lesion.

Original languageEnglish (US)
Pages (from-to)145-153
Number of pages9
JournalArthritis Research
Volume2
Issue number2
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Synovitis
Matrix Metalloproteinase 2
Matrix Metalloproteinase 14
Tissue Inhibitor of Metalloproteinase-2
Synovial Membrane
Matrix Metalloproteinase 9
Healthy Volunteers
Staining and Labeling
Serum

Keywords

  • Early synovitis
  • Erosion
  • Matrix metalloproteinse-2
  • Metalloproteinase
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Goldbach-Mansky, R., Lee, J. M., Hoxworth, J. M., Smith, D., Duray, P., Schumacher, H. R., ... Kleiner, D. (2000). Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis. Arthritis Research, 2(2), 145-153. https://doi.org/10.1186/ar79

Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis. / Goldbach-Mansky, R.; Lee, J. M.; Hoxworth, J. M.; Smith, D.; Duray, P.; Schumacher, H. R.; Yarboro, C. H.; Klippel, J.; Kleiner, D.; El-Gabalawy, H. S.; Duray, P.; Kleiner, D.

In: Arthritis Research, Vol. 2, No. 2, 2000, p. 145-153.

Research output: Contribution to journalArticle

Goldbach-Mansky, R, Lee, JM, Hoxworth, JM, Smith, D, Duray, P, Schumacher, HR, Yarboro, CH, Klippel, J, Kleiner, D, El-Gabalawy, HS, Duray, P & Kleiner, D 2000, 'Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis', Arthritis Research, vol. 2, no. 2, pp. 145-153. https://doi.org/10.1186/ar79
Goldbach-Mansky, R. ; Lee, J. M. ; Hoxworth, J. M. ; Smith, D. ; Duray, P. ; Schumacher, H. R. ; Yarboro, C. H. ; Klippel, J. ; Kleiner, D. ; El-Gabalawy, H. S. ; Duray, P. ; Kleiner, D. / Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis. In: Arthritis Research. 2000 ; Vol. 2, No. 2. pp. 145-153.
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