Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis

R. Goldbach-Mansky, J. M. Lee, J. M. Hoxworth, D. Smith, P. Duray, H. R. Schumacher, C. H. Yarboro, J. Klippel, D. Kleiner, H. S. El-Gabalawy, P. Duray, D. Kleiner

Research output: Contribution to journalArticle

71 Scopus citations

Abstract

Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients. Immunohistological staining of MMP-2, MMP-14 and TIMP-2 localized to corresponding areas in the synovial lining layer and was almost absent in normal synovium. Patients with radiographic erosions had significantly higher levels of active MMP-2 than patients with no erosions, suggesting that activated MMP-2 levels in synovial tissue may be a marker for a more aggressive synovial lesion.

Original languageEnglish (US)
Pages (from-to)145-153
Number of pages9
JournalArthritis Research
Volume2
Issue number2
DOIs
StatePublished - 2000

Keywords

  • Early synovitis
  • Erosion
  • Matrix metalloproteinse-2
  • Metalloproteinase
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Rheumatology

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    Goldbach-Mansky, R., Lee, J. M., Hoxworth, J. M., Smith, D., Duray, P., Schumacher, H. R., Yarboro, C. H., Klippel, J., Kleiner, D., El-Gabalawy, H. S., Duray, P., & Kleiner, D. (2000). Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis. Arthritis Research, 2(2), 145-153. https://doi.org/10.1186/ar79