Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis

R. Goldbach-Mansky; J. M. Lee; J. M. Hoxworth; D. Smith; P. Duray; H. R. Schumacher; C. H. Yarboro; J. Klippel; D. Kleiner; H. S. El-Gabalawy; P. Duray; D. Kleiner

doi:10.1186/ar79

Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis

R. Goldbach-Mansky, J. M. Lee, J. M. Hoxworth, D. Smith, P. Duray, H. R. Schumacher, C. H. Yarboro, J. Klippel, D. Kleiner, H. S. El-Gabalawy, P. Duray, D. Kleiner

Diagnostic Radiology

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients. Immunohistological staining of MMP-2, MMP-14 and TIMP-2 localized to corresponding areas in the synovial lining layer and was almost absent in normal synovium. Patients with radiographic erosions had significantly higher levels of active MMP-2 than patients with no erosions, suggesting that activated MMP-2 levels in synovial tissue may be a marker for a more aggressive synovial lesion.

Original language	English (US)
Pages (from-to)	145-153
Number of pages	9
Journal	Arthritis Research
Volume	2
Issue number	2
DOIs	https://doi.org/10.1186/ar79
State	Published - 2000

Keywords

Early synovitis
Erosion
Matrix metalloproteinse-2
Metalloproteinase
Rheumatoid arthritis

ASJC Scopus subject areas

Rheumatology

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10.1186/ar79

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title = "Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis",

abstract = "Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients. Immunohistological staining of MMP-2, MMP-14 and TIMP-2 localized to corresponding areas in the synovial lining layer and was almost absent in normal synovium. Patients with radiographic erosions had significantly higher levels of active MMP-2 than patients with no erosions, suggesting that activated MMP-2 levels in synovial tissue may be a marker for a more aggressive synovial lesion.",

keywords = "Early synovitis, Erosion, Matrix metalloproteinse-2, Metalloproteinase, Rheumatoid arthritis",

author = "R. Goldbach-Mansky and Lee, {J. M.} and Hoxworth, {J. M.} and D. Smith and P. Duray and Schumacher, {H. R.} and Yarboro, {C. H.} and J. Klippel and D. Kleiner and El-Gabalawy, {H. S.} and P. Duray and D. Kleiner",

year = "2000",

doi = "10.1186/ar79",

language = "English (US)",

volume = "2",

pages = "145--153",

journal = "Arthritis Research",

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T1 - Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis

AU - Goldbach-Mansky, R.

AU - Lee, J. M.

AU - Hoxworth, J. M.

AU - Smith, D.

AU - Duray, P.

AU - Schumacher, H. R.

AU - Yarboro, C. H.

AU - Klippel, J.

AU - Kleiner, D.

AU - El-Gabalawy, H. S.

AU - Duray, P.

AU - Kleiner, D.

PY - 2000

Y1 - 2000

N2 - Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients. Immunohistological staining of MMP-2, MMP-14 and TIMP-2 localized to corresponding areas in the synovial lining layer and was almost absent in normal synovium. Patients with radiographic erosions had significantly higher levels of active MMP-2 than patients with no erosions, suggesting that activated MMP-2 levels in synovial tissue may be a marker for a more aggressive synovial lesion.

AB - Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy volunteers and correlated with the presence of erosions in the patients. Immunohistological staining of MMP-2, MMP-14 and TIMP-2 localized to corresponding areas in the synovial lining layer and was almost absent in normal synovium. Patients with radiographic erosions had significantly higher levels of active MMP-2 than patients with no erosions, suggesting that activated MMP-2 levels in synovial tissue may be a marker for a more aggressive synovial lesion.

KW - Early synovitis

KW - Erosion

KW - Matrix metalloproteinse-2

KW - Metalloproteinase

KW - Rheumatoid arthritis

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ER -

Active synovial matrix metalloproteinase-2 is associated with radiographic erosions in patients with early synovitis

Abstract

Keywords

ASJC Scopus subject areas

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