TY - JOUR
T1 - Active and passive cigarette smoking and the risk of endometrial cancer in Poland
AU - Yang, Hannah P.
AU - Brinton, Louise A.
AU - Platz, Elizabeth A.
AU - Lissowska, Jolanta
AU - Lacey, James V.
AU - Sherman, Mark E.
AU - Peplonska, Beata
AU - Garcia-Closas, Montserrat
N1 - Funding Information:
The authors would like to thank Neonila Szeszenia-Dabrowska of the Nofer Institute of Occupational Medicine (Łódz, Poland) and Witold Zatonski of the M. Sklodowska-Curie Institute of Oncology and Cancer Centre (Warsaw, Poland) for their contribution to the Polish Endometrial Cancer Study. Pei Chao and Michael Stagner (IMS, Silver Spring, MD, USA) have been invaluable to the management of the study. This work would not be possible without the dedicated efforts of the physicians, nurses, interviewers and study participants. This research was supported by funds from the intramural programme of the National Cancer Institute, National Institutes of Health.
PY - 2010/3
Y1 - 2010/3
N2 - Background: Epidemiological studies have consistently reported that active cigarette smoking is inversely associated with endometrial cancer risk. However, dose-response relationships with quantitative measures of active smoking or passive smoking remain less clear. Methods: Data on lifetime active and passive smoking were collected for 551 endometrial cancer cases and 1925 controls in a population-based case-control study conducted during 2001-2003 in Poland (Warsaw and Łódz). Results: Compared with never active smokers, active current (Odds Ratio (OR) = 0.51, 95% Confidence Interval (CI): 0.39, 0.68) and former smokers (OR = 0.60, 95% CI: 0.45, 0.80) were at a statistically significantly decreased risk. We did not observe statistically significant inverse dose-response relationships with increasing exposure with duration and cumulative measures. However, there was some indication that the highest category of number of years (OR = 0.35, 95% CI: 0.23-0.55), intensity (OR = 0.41, 95% CI: 0.24-0.69), and dose (OR = 0.38, 95% CI: 0.24-0.60) of smoking among current smokers had the greatest inverse association compared to never smokers. Our data did not support the presence of an inverse association with passive smoking among never active smokers (OR = 0.92; 95% CI: 0.65, 1.29). Conclusion: Our results support that long-term and heavy smoking among current smokers strongly influence endometrial cancer risk.
AB - Background: Epidemiological studies have consistently reported that active cigarette smoking is inversely associated with endometrial cancer risk. However, dose-response relationships with quantitative measures of active smoking or passive smoking remain less clear. Methods: Data on lifetime active and passive smoking were collected for 551 endometrial cancer cases and 1925 controls in a population-based case-control study conducted during 2001-2003 in Poland (Warsaw and Łódz). Results: Compared with never active smokers, active current (Odds Ratio (OR) = 0.51, 95% Confidence Interval (CI): 0.39, 0.68) and former smokers (OR = 0.60, 95% CI: 0.45, 0.80) were at a statistically significantly decreased risk. We did not observe statistically significant inverse dose-response relationships with increasing exposure with duration and cumulative measures. However, there was some indication that the highest category of number of years (OR = 0.35, 95% CI: 0.23-0.55), intensity (OR = 0.41, 95% CI: 0.24-0.69), and dose (OR = 0.38, 95% CI: 0.24-0.60) of smoking among current smokers had the greatest inverse association compared to never smokers. Our data did not support the presence of an inverse association with passive smoking among never active smokers (OR = 0.92; 95% CI: 0.65, 1.29). Conclusion: Our results support that long-term and heavy smoking among current smokers strongly influence endometrial cancer risk.
KW - Active smoking
KW - Endometrial cancer
KW - Passive smoking
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U2 - 10.1016/j.ejca.2009.11.015
DO - 10.1016/j.ejca.2009.11.015
M3 - Article
C2 - 20036529
AN - SCOPUS:76249118149
SN - 0959-8049
VL - 46
SP - 690
EP - 696
JO - European Journal of Cancer
JF - European Journal of Cancer
IS - 4
ER -