Abstract
The t(5;14)(q31;q32) translocation from B-lineage acute lymphocytic leukemia with eosinophilia has been cloned from two leukemia samples. In both cases, this translocation joined the IgH gene and the interleukin-3 (IL-3) gene. In one patient, excess IL-3 mRNA was produced by the leukemia cells. In the second patient, serum IL-3 levels were measured and shown to correlate with disease activity. There was no evidence of excess granulocyte/ macrophage colony stimulating factor (GM-CSF) or IL-5 expression. Our data support the formulation that this subtype of leukemia may arise in part because of a chromosome translocation that activates the IL-3 gene, resulting in autocrine and paracrine growth effects.
Original language | English (US) |
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Pages (from-to) | 285-289 |
Number of pages | 5 |
Journal | Blood |
Volume | 76 |
Issue number | 2 |
State | Published - Jul 15 1990 |
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology