Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia

T. C. Meeker, D. Hardy, C. Willman, T. Hogan, J. Abrams

Research output: Contribution to journalArticlepeer-review

Abstract

The t(5;14)(q31;q32) translocation from B-lineage acute lymphocytic leukemia with eosinophilia has been cloned from two leukemia samples. In both cases, this translocation joined the IgH gene and the interleukin-3 (IL-3) gene. In one patient, excess IL-3 mRNA was produced by the leukemic cells. In the second patient, serum IL-3 levels were measured and shown to correlate with disease activity. There was no evidence of excess granulocyte/macrophage colony stimulating factor (GM-CSF) or IL-5 expression. Our data support the formulation that this subtype of leukemia may arise in part because of a chromosome translocation that activates the IL-3 gene, resulting in autocrine and paracrine growth effects.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalBlood
Volume76
Issue number2
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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