Activated mouse eosinophils protect against lethal respiratory virus infection

Caroline M. Percopo, Kimberly D. Dyer, Sergei I. Ochkur, Janice L. Luo, Elizabeth R. Fischer, James J. Lee, Nancy A Lee, Joseph B. Domachowske, Helene F. Rosenberg

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Eosinophils are recruited to the airways as a prominent feature of the asthmatic inflammatory response where they are broadly perceived as promoting pathophysiology. Respiratory virus infections exacerbate established asthma; however, the role of eosinophils and the nature of their interactions with respiratory viruses remain uncertain. To explore these questions, we established acute infection with the rodent pneumovirus, pneumonia virus of mice (PVM), in 3 distinct mouse models of Th2 cytokine-driven asthmatic inflammation. We found that eosinophils recruited to the airways of otherwise naïve mice in response to Aspergillus fumigatus, but not ovalbumin sensitization and challenge, are activated by and degranulate specifically in response to PVM infection. Furthermore, we demonstrate that activated eosinophils from both Aspergillus antigen and cytokine-driven asthma models are profoundly antiviral and promote survival in response to an otherwise lethal PVM infection. Thus, although activated eosinophils within a Th2-polarized inflammatory response may have pathophysiologic features, they are also efficient and effective mediators of antiviral host defense.

Original languageEnglish (US)
Pages (from-to)743-752
Number of pages10
JournalBlood
Volume123
Issue number5
DOIs
StatePublished - Jan 30 2014

Fingerprint

Virus Diseases
Murine pneumonia virus
Viruses
Eosinophils
Respiratory Tract Infections
Aspergillus
Antiviral Agents
Pneumovirus
Asthma
Cytokines
Aspergillus fumigatus
Ovalbumin
Rodentia
Inflammation
Antigens
Infection

ASJC Scopus subject areas

  • Hematology
  • Biochemistry
  • Cell Biology
  • Immunology

Cite this

Percopo, C. M., Dyer, K. D., Ochkur, S. I., Luo, J. L., Fischer, E. R., Lee, J. J., ... Rosenberg, H. F. (2014). Activated mouse eosinophils protect against lethal respiratory virus infection. Blood, 123(5), 743-752. https://doi.org/10.1182/blood-2013-05-502443

Activated mouse eosinophils protect against lethal respiratory virus infection. / Percopo, Caroline M.; Dyer, Kimberly D.; Ochkur, Sergei I.; Luo, Janice L.; Fischer, Elizabeth R.; Lee, James J.; Lee, Nancy A; Domachowske, Joseph B.; Rosenberg, Helene F.

In: Blood, Vol. 123, No. 5, 30.01.2014, p. 743-752.

Research output: Contribution to journalArticle

Percopo, CM, Dyer, KD, Ochkur, SI, Luo, JL, Fischer, ER, Lee, JJ, Lee, NA, Domachowske, JB & Rosenberg, HF 2014, 'Activated mouse eosinophils protect against lethal respiratory virus infection', Blood, vol. 123, no. 5, pp. 743-752. https://doi.org/10.1182/blood-2013-05-502443
Percopo CM, Dyer KD, Ochkur SI, Luo JL, Fischer ER, Lee JJ et al. Activated mouse eosinophils protect against lethal respiratory virus infection. Blood. 2014 Jan 30;123(5):743-752. https://doi.org/10.1182/blood-2013-05-502443
Percopo, Caroline M. ; Dyer, Kimberly D. ; Ochkur, Sergei I. ; Luo, Janice L. ; Fischer, Elizabeth R. ; Lee, James J. ; Lee, Nancy A ; Domachowske, Joseph B. ; Rosenberg, Helene F. / Activated mouse eosinophils protect against lethal respiratory virus infection. In: Blood. 2014 ; Vol. 123, No. 5. pp. 743-752.
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