ACR Appropriateness Criteria® Ovarian Cancer Screening

Pari V. Pandharipande, Kathryn P. Lowry, Caroline Reinhold, Mostafa Atri, Carol B. Benson, Priyadarshani R. Bhosale, Edward D. Green, Stella K. Kang, Yulia Lakhman, Katherine E. Maturen, Refky Nicola, Gloria M. Salazar, Thomas D. Shipp, Lynn Simpson, Betsy L. Sussman, Jennifer Uyeda, Darci J. Wall, Bradford Whitcomb, Carolyn M. Zelop, Phyllis GlancExpert Panel on Women's Imaging

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

There has been much interest in the identification of a successful ovarian cancer screening test, in particular, one that can detect ovarian cancer at an early stage and improve survival. We reviewed the currently available data from randomized and observational trials that examine the role of imaging for ovarian cancer screening in average-risk and high-risk women. We found insufficient evidence to recommend ovarian cancer screening, when considering the imaging modality (pelvic ultrasound) and population (average-risk postmenopausal women) for which there is the greatest available published evidence; randomized controlled trials have not demonstrated a mortality benefit in this setting. Screening high-risk women using pelvic ultrasound may be appropriate in some clinical situations; however, related data are limited because large, randomized trials have not been performed in this setting. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.

Original languageEnglish (US)
Pages (from-to)S490-S499
JournalJournal of the American College of Radiology
Volume14
Issue number11
DOIs
StatePublished - Nov 1 2017

Keywords

  • Appropriate Use Criteria
  • Appropriateness Criteria
  • AUC
  • CA-125
  • Cancer screening
  • Ovarian cancer
  • Pelvic US

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Pandharipande, P. V., Lowry, K. P., Reinhold, C., Atri, M., Benson, C. B., Bhosale, P. R., Green, E. D., Kang, S. K., Lakhman, Y., Maturen, K. E., Nicola, R., Salazar, G. M., Shipp, T. D., Simpson, L., Sussman, B. L., Uyeda, J., Wall, D. J., Whitcomb, B., Zelop, C. M., ... Expert Panel on Women's Imaging (2017). ACR Appropriateness Criteria® Ovarian Cancer Screening. Journal of the American College of Radiology, 14(11), S490-S499. https://doi.org/10.1016/j.jacr.2017.08.049