TY - JOUR
T1 - Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis
AU - Aaen, Gregory
AU - Waltz, Michael
AU - Vargas, Wendy
AU - Makhani, Naila
AU - Ness, Jayne
AU - Harris, Yolanda
AU - Casper, T. Charles
AU - Benson, Leslie
AU - Candee, Meghan
AU - Chitnis, Tanuja
AU - Gorman, Mark
AU - Graves, Jennifer
AU - Greenberg, Benjamin
AU - Lotze, Timothy
AU - Mar, Soe
AU - Tillema, Jan Mendelt
AU - Rensel, Mary
AU - Rodriguez, Moses
AU - Rose, John
AU - Rubin, Jennifer
AU - Schreiner, Teri
AU - Waldman, Amy
AU - Weinstock-Guttman, Bianca
AU - Belman, Anita
AU - Waubant, Emmanuelle
AU - Krupp, Lauren
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported in part by the NIH NINDS: lRO1NS071463 (PI Waubant) and the National MS Society HC 0165 (PI Casper).
Publisher Copyright:
© The Author(s) 2018.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Children with pediatric-onset multiple sclerosis and pediatric controls were enrolled across 16 pediatric multiple sclerosis centers in the United States and completed questionnaires that addressed time of first unaided walking and acquisition of 2-word phrases. A total of 467 (308 female) cases and 428 (209 female) controls were enrolled. Pediatric multiple sclerosis (n = 467) were not delayed in walking or using 2-word phrases compared to healthy controls (n = 428) (2.2% vs 5.7%, respectively). Children with disease onset before age 11 versus onset at 11 years or after were more likely to need an individualized education plan (P =.002), reading assistance (P =.0003), and math assistance (P =.001). Children with multiple sclerosis onset prior to age 18 are not delayed in meeting the 2 major early developmental milestones but do have a significantly increased use of special services or learning assistance at school. Further research will need to address whether other measures of development (eg, rate of language acquisition or fine motor skills) differ between pediatric multiple sclerosis and controls.
AB - Children with pediatric-onset multiple sclerosis and pediatric controls were enrolled across 16 pediatric multiple sclerosis centers in the United States and completed questionnaires that addressed time of first unaided walking and acquisition of 2-word phrases. A total of 467 (308 female) cases and 428 (209 female) controls were enrolled. Pediatric multiple sclerosis (n = 467) were not delayed in walking or using 2-word phrases compared to healthy controls (n = 428) (2.2% vs 5.7%, respectively). Children with disease onset before age 11 versus onset at 11 years or after were more likely to need an individualized education plan (P =.002), reading assistance (P =.0003), and math assistance (P =.001). Children with multiple sclerosis onset prior to age 18 are not delayed in meeting the 2 major early developmental milestones but do have a significantly increased use of special services or learning assistance at school. Further research will need to address whether other measures of development (eg, rate of language acquisition or fine motor skills) differ between pediatric multiple sclerosis and controls.
KW - cognitive impairment
KW - developmental milestones
KW - multiple sclerosis
KW - pediatric
UR - http://www.scopus.com/inward/record.url?scp=85060204388&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85060204388&partnerID=8YFLogxK
U2 - 10.1177/0883073818815041
DO - 10.1177/0883073818815041
M3 - Article
C2 - 30556452
AN - SCOPUS:85060204388
SN - 0883-0738
VL - 34
SP - 148
EP - 152
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 3
ER -