Acquired QT prolongation associated with esophagitis and acute weight loss

How to evaluate a prolonged QT interval

J. J. Koch, C. J. Porter, Michael John Ackerman

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

When the physician is confronted with a patient having significant QT prolongation, it is critical to determine whether the patient harbors a genetic defect and a transmissible form of long QT syndrome (LQTS) or whether the QT prolongation has an acquired cause. The distinction has profound ramifications for the type of care provided to the patient and family. We report the case of a previously healthy 14-year-old boy who presented with a 10-day history of painful swallowing, a 10-lb weight loss, and chest pain. A 12-lead electrocardiogram (ECG) showed marked QT prolongation. Endoscopy and culture identified a Herpes simplex esophageal ulcer. After treatment with acyclovir, the patient recovered completely. Three weeks after the resolution of his symptoms and recovery from his acute weight loss, a follow-up ECG showed complete normalization of the QT interval. This case illustrates yet another potential mechanism for acquired QT prolongation. We also provide a diagnostic algorithm for the careful evaluation of a prolonged QT interval.

Original languageEnglish (US)
Pages (from-to)646-650
Number of pages5
JournalPediatric Cardiology
Volume26
Issue number5
DOIs
StatePublished - Oct 2005

Fingerprint

Esophagitis
Weight Loss
Electrocardiography
Long QT Syndrome
Herpes Simplex
Acyclovir
Deglutition
Chest Pain
Endoscopy
Ulcer
Physicians
Therapeutics

Keywords

  • Electrocardiography
  • Esophagitis
  • Long QT syndrome
  • QT interval
  • Torsades de pointes
  • Weight loss

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health

Cite this

Acquired QT prolongation associated with esophagitis and acute weight loss : How to evaluate a prolonged QT interval. / Koch, J. J.; Porter, C. J.; Ackerman, Michael John.

In: Pediatric Cardiology, Vol. 26, No. 5, 10.2005, p. 646-650.

Research output: Contribution to journalArticle

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