Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes

Ronald S. Go, Chin Yang Li, Ayalew Tefferi, Robert L. Phyliky

Research output: Contribution to journalArticle

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Abstract

Acquired pure red cell aplasia (PRCA) can be associated with lymphoproliferative disease of granular T lymphocytes (T-LDGL), also known as T-cell large granular lymphocyte leukemia. Fifteen adult patients with PRCA associated with T-LDGL comprise this study. Neutropenia and rheumatoid arthritis were uncommon. All patients responded to immunosuppressive therapy. The 2 most commonly used treatments were prednisone and cyclophosphamide ± corticosteroids, producing overall response rates of 50% and 60%, respectively. Treatment with cyclophosphamide was associated with a more durable remission (median, 60 versus 7.5 months). After a median follow-up of 67 months, 2 patients died of treatmentrelated complications, one from myelodysplasia and another from cyclosporine-induced renal failure. The clinical course and treatment responses of PRCA associated with T-LDGL in this series were similar to the general group of PRCA. Because T-LDGL is frequently underdiagnosed, it is likely that a significant proportion of idiopathic or primary PRCA is in fact secondary to T-LDGL.

Original languageEnglish (US)
Pages (from-to)483-485
Number of pages3
JournalBlood
Volume98
Issue number2
DOIs
StatePublished - Jul 15 2001

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Large Granular Lymphocytic Leukemia
Pure Red-Cell Aplasia
T-cells
Cyclophosphamide
Cells
T-Lymphocytes
Lymphocytes
Immunosuppressive Agents
Prednisone
Cyclosporine
Adrenal Cortex Hormones
Therapeutics
Neutropenia
Renal Insufficiency
Rheumatoid Arthritis

ASJC Scopus subject areas

  • Hematology

Cite this

Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes. / Go, Ronald S.; Li, Chin Yang; Tefferi, Ayalew; Phyliky, Robert L.

In: Blood, Vol. 98, No. 2, 15.07.2001, p. 483-485.

Research output: Contribution to journalArticle

Go, Ronald S. ; Li, Chin Yang ; Tefferi, Ayalew ; Phyliky, Robert L. / Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes. In: Blood. 2001 ; Vol. 98, No. 2. pp. 483-485.
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