Acquired motor neuron disorders

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The acquired motor neuron disorders are diverse conditions characterized by weakness and preserved sensory function. The cause of most of these disorders is poorly understood, and treatment is mainly supportive. ALS, the most common motor neuron disorder seen in practice, has UMN and-LMN signs, and typically begins focally, with diffuse spread to involve limb, bulbar, and respiratory muscles, causing death from respiratory failure. The cause of ALS is not known, but new evidence suggests that oxidative injury and a disturbance in glutamate metabolism play major roles. Riluzole slows progression slightly, and neurotrophic factors are being tested for possible benefit. Combination therapy for ALS is envisioned for the near future. Post- polio syndrome occurs many years after recovering from polio, and often involves fatigue and pain. Progression of weakness may occur, but is uncommon. Of several LMN syndromes, multifocal motor neuropathy must be sought by careful assessment for motor conduction block because this syndrome may mimic ALS, and is reversible with immune-modulating treatment.

Original languageEnglish (US)
Pages (from-to)481-500
Number of pages20
JournalNeurologic Clinics
Volume15
Issue number3
DOIs
StatePublished - 1997
Externally publishedYes

Fingerprint

Motor Neurons
Postpoliomyelitis Syndrome
Riluzole
Respiratory Muscles
Nerve Growth Factors
Poliomyelitis
Respiratory Insufficiency
Fatigue
Glutamic Acid
Therapeutics
Extremities
Pain
Wounds and Injuries
Motor Disorders

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Acquired motor neuron disorders. / Ross, Mark A.

In: Neurologic Clinics, Vol. 15, No. 3, 1997, p. 481-500.

Research output: Contribution to journalArticle

Ross, Mark A. / Acquired motor neuron disorders. In: Neurologic Clinics. 1997 ; Vol. 15, No. 3. pp. 481-500.
@article{f4199df7734e42aebe9f1c1a4cd8989b,
title = "Acquired motor neuron disorders",
abstract = "The acquired motor neuron disorders are diverse conditions characterized by weakness and preserved sensory function. The cause of most of these disorders is poorly understood, and treatment is mainly supportive. ALS, the most common motor neuron disorder seen in practice, has UMN and-LMN signs, and typically begins focally, with diffuse spread to involve limb, bulbar, and respiratory muscles, causing death from respiratory failure. The cause of ALS is not known, but new evidence suggests that oxidative injury and a disturbance in glutamate metabolism play major roles. Riluzole slows progression slightly, and neurotrophic factors are being tested for possible benefit. Combination therapy for ALS is envisioned for the near future. Post- polio syndrome occurs many years after recovering from polio, and often involves fatigue and pain. Progression of weakness may occur, but is uncommon. Of several LMN syndromes, multifocal motor neuropathy must be sought by careful assessment for motor conduction block because this syndrome may mimic ALS, and is reversible with immune-modulating treatment.",
author = "Ross, {Mark A}",
year = "1997",
doi = "10.1016/S0733-8619(05)70330-3",
language = "English (US)",
volume = "15",
pages = "481--500",
journal = "Neurologic Clinics",
issn = "0733-8619",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Acquired motor neuron disorders

AU - Ross, Mark A

PY - 1997

Y1 - 1997

N2 - The acquired motor neuron disorders are diverse conditions characterized by weakness and preserved sensory function. The cause of most of these disorders is poorly understood, and treatment is mainly supportive. ALS, the most common motor neuron disorder seen in practice, has UMN and-LMN signs, and typically begins focally, with diffuse spread to involve limb, bulbar, and respiratory muscles, causing death from respiratory failure. The cause of ALS is not known, but new evidence suggests that oxidative injury and a disturbance in glutamate metabolism play major roles. Riluzole slows progression slightly, and neurotrophic factors are being tested for possible benefit. Combination therapy for ALS is envisioned for the near future. Post- polio syndrome occurs many years after recovering from polio, and often involves fatigue and pain. Progression of weakness may occur, but is uncommon. Of several LMN syndromes, multifocal motor neuropathy must be sought by careful assessment for motor conduction block because this syndrome may mimic ALS, and is reversible with immune-modulating treatment.

AB - The acquired motor neuron disorders are diverse conditions characterized by weakness and preserved sensory function. The cause of most of these disorders is poorly understood, and treatment is mainly supportive. ALS, the most common motor neuron disorder seen in practice, has UMN and-LMN signs, and typically begins focally, with diffuse spread to involve limb, bulbar, and respiratory muscles, causing death from respiratory failure. The cause of ALS is not known, but new evidence suggests that oxidative injury and a disturbance in glutamate metabolism play major roles. Riluzole slows progression slightly, and neurotrophic factors are being tested for possible benefit. Combination therapy for ALS is envisioned for the near future. Post- polio syndrome occurs many years after recovering from polio, and often involves fatigue and pain. Progression of weakness may occur, but is uncommon. Of several LMN syndromes, multifocal motor neuropathy must be sought by careful assessment for motor conduction block because this syndrome may mimic ALS, and is reversible with immune-modulating treatment.

UR - http://www.scopus.com/inward/record.url?scp=0030853444&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030853444&partnerID=8YFLogxK

U2 - 10.1016/S0733-8619(05)70330-3

DO - 10.1016/S0733-8619(05)70330-3

M3 - Article

C2 - 9227949

AN - SCOPUS:0030853444

VL - 15

SP - 481

EP - 500

JO - Neurologic Clinics

JF - Neurologic Clinics

SN - 0733-8619

IS - 3

ER -