Acoustic radiation force optical coherence elastography for evaluating mechanical properties of soft condensed matters and its biological applications

Hsiao Chuan Liu, Piotr Kijanka, Matthew W. Urban

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Evaluating mechanical properties of biological soft tissues and viscous mucus is challenging because of complicated dynamic behaviors. Soft condensed matter models have been successfully used to explain a number of dynamical behaviors. Here, we reported that optical coherence elastography (OCE) is capable of quantifying mechanical properties of soft condensed matters, micellar fluids. A 7.5 MHz focused transducer was utilized to generate acoustic radiation force exerted on the surface of soft condensed matters in order to produce Rayleigh waves. The waves were recorded by optical coherence tomography (OCT). The Kelvin-Voigt model was adopted to evaluate shear modulus and loss modulus of soft condensed matters. The results reported that various concentrations of micellar fluids can provide reasonable ranges of elasticity from 65.71 to 428.78 Pa and viscosity from 0.035 to 0.283 Pa·s, which are close to ranges for actual biological samples, like mucus. OCE might be a promising tool to differentiate pathologic mucus samples from healthy cases as advanced applications in the future.

Original languageEnglish (US)
Article numbere201960134
JournalJournal of biophotonics
Volume13
Issue number3
DOIs
StatePublished - Mar 1 2020

Keywords

  • acoustic radiation force
  • micellar fluid
  • optical coherence elastography
  • optical coherence tomography
  • soft condensed matter
  • ultrasound

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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