ACL graft metabolic activity assessed by 18FDG PET–MRI

Robert A. Magnussen, Katherine Binzel, Jun Zhang, Wenbo Wei, Melanie U. Knopp, David C. Flanigan, Timothy Hewett, Christopher C. Kaeding, Michael V. Knopp

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background To demonstrate the use of 18Fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) in combination (18FDG-PET) to assess the metabolic activity of ACL graft tissue and evaluate the utility of this technique for ligament imaging. Methods Twenty-one knees with intact ACL grafts in 19 patients at multiple time points following ACL reconstruction were recruited to participate. PET–MRI imaging was performed using a custom device to place knees in the same position for both studies. Images were co-registered for quantification of 18FDG-PET standardized uptake value (SUV) for the proximal, middle, and distal ACL was quantified. Signal in extra-articular muscle tissue in the index knee was also recorded as a control. Signal from each location was compared based on how far post-operative each knee was from ACL reconstruction (< 6 months, six to 12 months, 12–24 months, or > 24 months). Results Significant differences in 18FDG PET SUV between the four time points were observed in the proximal (p = 0.02), middle (p = 0.004), and distal (p = 0.007) portions of the ACL graft. The greater than 24 months group was noted to be different from other groups in each case. No difference in PET 18FDG SUV was noted in the extra-articular muscle in the index knee in each time group (p = 0.61). Conclusions Metabolic activity was noted to be significantly lower in grafts imaged greater than two years post-reconstruction relative to those grafts that had been in place for shorter periods of time.

Original languageEnglish (US)
Pages (from-to)792-797
Number of pages6
JournalKnee
Volume24
Issue number4
DOIs
StatePublished - Aug 1 2017

Fingerprint

Fluorodeoxyglucose F18
Positron-Emission Tomography
Knee
Transplants
Joints
Muscles
Ligaments
Magnetic Resonance Imaging
Equipment and Supplies

Keywords

  • FDG
  • ACL reconstruction
  • Ligamentization
  • Magnetic resonance imaging
  • Positron emission tomography

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

A. Magnussen, R., Binzel, K., Zhang, J., Wei, W., U. Knopp, M., C. Flanigan, D., ... V. Knopp, M. (2017). ACL graft metabolic activity assessed by 18FDG PET–MRI. Knee, 24(4), 792-797. https://doi.org/10.1016/j.knee.2017.04.008

ACL graft metabolic activity assessed by 18FDG PET–MRI. / A. Magnussen, Robert; Binzel, Katherine; Zhang, Jun; Wei, Wenbo; U. Knopp, Melanie; C. Flanigan, David; Hewett, Timothy; C. Kaeding, Christopher; V. Knopp, Michael.

In: Knee, Vol. 24, No. 4, 01.08.2017, p. 792-797.

Research output: Contribution to journalArticle

A. Magnussen, R, Binzel, K, Zhang, J, Wei, W, U. Knopp, M, C. Flanigan, D, Hewett, T, C. Kaeding, C & V. Knopp, M 2017, 'ACL graft metabolic activity assessed by 18FDG PET–MRI', Knee, vol. 24, no. 4, pp. 792-797. https://doi.org/10.1016/j.knee.2017.04.008
A. Magnussen R, Binzel K, Zhang J, Wei W, U. Knopp M, C. Flanigan D et al. ACL graft metabolic activity assessed by 18FDG PET–MRI. Knee. 2017 Aug 1;24(4):792-797. https://doi.org/10.1016/j.knee.2017.04.008
A. Magnussen, Robert ; Binzel, Katherine ; Zhang, Jun ; Wei, Wenbo ; U. Knopp, Melanie ; C. Flanigan, David ; Hewett, Timothy ; C. Kaeding, Christopher ; V. Knopp, Michael. / ACL graft metabolic activity assessed by 18FDG PET–MRI. In: Knee. 2017 ; Vol. 24, No. 4. pp. 792-797.
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abstract = "Background To demonstrate the use of 18Fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) in combination (18FDG-PET) to assess the metabolic activity of ACL graft tissue and evaluate the utility of this technique for ligament imaging. Methods Twenty-one knees with intact ACL grafts in 19 patients at multiple time points following ACL reconstruction were recruited to participate. PET–MRI imaging was performed using a custom device to place knees in the same position for both studies. Images were co-registered for quantification of 18FDG-PET standardized uptake value (SUV) for the proximal, middle, and distal ACL was quantified. Signal in extra-articular muscle tissue in the index knee was also recorded as a control. Signal from each location was compared based on how far post-operative each knee was from ACL reconstruction (< 6 months, six to 12 months, 12–24 months, or > 24 months). Results Significant differences in 18FDG PET SUV between the four time points were observed in the proximal (p = 0.02), middle (p = 0.004), and distal (p = 0.007) portions of the ACL graft. The greater than 24 months group was noted to be different from other groups in each case. No difference in PET 18FDG SUV was noted in the extra-articular muscle in the index knee in each time group (p = 0.61). Conclusions Metabolic activity was noted to be significantly lower in grafts imaged greater than two years post-reconstruction relative to those grafts that had been in place for shorter periods of time.",
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AU - A. Magnussen, Robert

AU - Binzel, Katherine

AU - Zhang, Jun

AU - Wei, Wenbo

AU - U. Knopp, Melanie

AU - C. Flanigan, David

AU - Hewett, Timothy

AU - C. Kaeding, Christopher

AU - V. Knopp, Michael

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N2 - Background To demonstrate the use of 18Fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) in combination (18FDG-PET) to assess the metabolic activity of ACL graft tissue and evaluate the utility of this technique for ligament imaging. Methods Twenty-one knees with intact ACL grafts in 19 patients at multiple time points following ACL reconstruction were recruited to participate. PET–MRI imaging was performed using a custom device to place knees in the same position for both studies. Images were co-registered for quantification of 18FDG-PET standardized uptake value (SUV) for the proximal, middle, and distal ACL was quantified. Signal in extra-articular muscle tissue in the index knee was also recorded as a control. Signal from each location was compared based on how far post-operative each knee was from ACL reconstruction (< 6 months, six to 12 months, 12–24 months, or > 24 months). Results Significant differences in 18FDG PET SUV between the four time points were observed in the proximal (p = 0.02), middle (p = 0.004), and distal (p = 0.007) portions of the ACL graft. The greater than 24 months group was noted to be different from other groups in each case. No difference in PET 18FDG SUV was noted in the extra-articular muscle in the index knee in each time group (p = 0.61). Conclusions Metabolic activity was noted to be significantly lower in grafts imaged greater than two years post-reconstruction relative to those grafts that had been in place for shorter periods of time.

AB - Background To demonstrate the use of 18Fluorodeoxyglucose positron emission tomography (PET) and magnetic resonance imaging (MRI) in combination (18FDG-PET) to assess the metabolic activity of ACL graft tissue and evaluate the utility of this technique for ligament imaging. Methods Twenty-one knees with intact ACL grafts in 19 patients at multiple time points following ACL reconstruction were recruited to participate. PET–MRI imaging was performed using a custom device to place knees in the same position for both studies. Images were co-registered for quantification of 18FDG-PET standardized uptake value (SUV) for the proximal, middle, and distal ACL was quantified. Signal in extra-articular muscle tissue in the index knee was also recorded as a control. Signal from each location was compared based on how far post-operative each knee was from ACL reconstruction (< 6 months, six to 12 months, 12–24 months, or > 24 months). Results Significant differences in 18FDG PET SUV between the four time points were observed in the proximal (p = 0.02), middle (p = 0.004), and distal (p = 0.007) portions of the ACL graft. The greater than 24 months group was noted to be different from other groups in each case. No difference in PET 18FDG SUV was noted in the extra-articular muscle in the index knee in each time group (p = 0.61). Conclusions Metabolic activity was noted to be significantly lower in grafts imaged greater than two years post-reconstruction relative to those grafts that had been in place for shorter periods of time.

KW - FDG

KW - ACL reconstruction

KW - Ligamentization

KW - Magnetic resonance imaging

KW - Positron emission tomography

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