Acinar cell plasticity and development of pancreatic ductal adenocarcinoma

Research output: Contribution to journalReview article

67 Scopus citations

Abstract

Acinar cells in the adult pancreas show high plasticity and can undergo transdifferentiation to a progenitor-like cell type with ductal characteristics. This process, termed acinar-to-ductal metaplasia (ADM), is an important feature facilitating pancreas regeneration after injury. Data from animal models show that cells that undergo ADM in response to oncogenic signalling are precursors for pancreatic intraepithelial neoplasia lesions, which can further progress to pancreatic ductal adenocarcinoma (PDAC). As human pancreatic adenocarcinoma is often diagnosed at a stage of metastatic disease, understanding the processes that lead to its initiation is important for the discovery of markers for early detection, as well as options that enable an early intervention. Here, the critical determinants of acinar cell plasticity are discussed, in addition to the intracellular and extracellular signalling events that drive acinar cell metaplasia and their contribution to development of PDAC.

Original languageEnglish (US)
Pages (from-to)296-304
Number of pages9
JournalNature Reviews Gastroenterology and Hepatology
Volume14
Issue number5
DOIs
StatePublished - May 1 2017

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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