Acid blocking medication usage pre and post liver transplantation

J. Stauffer, H. Bonatti, K. Norman, C. Jean-Pierre, Justin H Nguyen, J. Gusler, J. Slocum, R. Hinder, S. Achem, K. De Vault, Rolland Dickson, Jaime Aranda-Michel

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Terminal liver disease is associated with upper gastrointestinal (GI) pathology. Following liver transplantation (LT), some immunosuppressive agents can cause GI complications. Methods: We investigated the use of acid blocking medication (ABM) pre and post transplant in a series of 467 consecutive LTs in 402 individuals, which were performed from 1998 to 2001 at our center. Results: A total of 41% of patients were given ABM pretransplant. All patients received proton pump inhibitors (PPIs) for 100 days per protocol. After a median follow up of 5 (range 1-8.1) years for 339 evaluate transplants, 64% of patients received ABM for peptic ulcer disease (n = 28), GERD (n = 50), dyspepsia/gastritis (n = 30), recurrent liver cirrhosis (n = 15) and prophylaxis if patients were maintained on steroids (n = 21), MMF (n = 17), Sirolimus (n = 9) or received biphosphonates for osteoporosis (n = 22). In a minority of cases no clear indication could be found. Conclusions: Upper GI diseases are common complications after LT and many LT recipients require long term ABM.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalEuropean Surgery - Acta Chirurgica Austriaca
Volume39
Issue number1
DOIs
StatePublished - 2007

Fingerprint

Liver Transplantation
Acids
Transplants
Proton Pump Inhibitors
Gastrointestinal Diseases
Dyspepsia
Gastritis
Sirolimus
Immunosuppressive Agents
Gastroesophageal Reflux
Peptic Ulcer
Liver Cirrhosis
Osteoporosis
Liver Diseases
Steroids
Pathology

Keywords

  • GERD
  • Liver transplantation
  • Peptic ulcer
  • Proton pump inhibitor

ASJC Scopus subject areas

  • Surgery

Cite this

Stauffer, J., Bonatti, H., Norman, K., Jean-Pierre, C., Nguyen, J. H., Gusler, J., ... Aranda-Michel, J. (2007). Acid blocking medication usage pre and post liver transplantation. European Surgery - Acta Chirurgica Austriaca, 39(1), 57-60. https://doi.org/10.1007/s10353-006-0302-4

Acid blocking medication usage pre and post liver transplantation. / Stauffer, J.; Bonatti, H.; Norman, K.; Jean-Pierre, C.; Nguyen, Justin H; Gusler, J.; Slocum, J.; Hinder, R.; Achem, S.; De Vault, K.; Dickson, Rolland; Aranda-Michel, Jaime.

In: European Surgery - Acta Chirurgica Austriaca, Vol. 39, No. 1, 2007, p. 57-60.

Research output: Contribution to journalArticle

Stauffer, J, Bonatti, H, Norman, K, Jean-Pierre, C, Nguyen, JH, Gusler, J, Slocum, J, Hinder, R, Achem, S, De Vault, K, Dickson, R & Aranda-Michel, J 2007, 'Acid blocking medication usage pre and post liver transplantation', European Surgery - Acta Chirurgica Austriaca, vol. 39, no. 1, pp. 57-60. https://doi.org/10.1007/s10353-006-0302-4
Stauffer, J. ; Bonatti, H. ; Norman, K. ; Jean-Pierre, C. ; Nguyen, Justin H ; Gusler, J. ; Slocum, J. ; Hinder, R. ; Achem, S. ; De Vault, K. ; Dickson, Rolland ; Aranda-Michel, Jaime. / Acid blocking medication usage pre and post liver transplantation. In: European Surgery - Acta Chirurgica Austriaca. 2007 ; Vol. 39, No. 1. pp. 57-60.
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