Acid blocking medication usage pre and post liver transplantation

J. Stauffer, H. Bonatti, K. Norman, C. Jean-Pierre, J. Nguyen, J. Gusler, J. Slocum, R. Hinder, S. Achem, K. De Vault, R. C. Dickson, Jaime Aranda-Michel

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: Terminal liver disease is associated with upper gastrointestinal (GI) pathology. Following liver transplantation (LT), some immunosuppressive agents can cause GI complications. Methods: We investigated the use of acid blocking medication (ABM) pre and post transplant in a series of 467 consecutive LTs in 402 individuals, which were performed from 1998 to 2001 at our center. Results: A total of 41% of patients were given ABM pretransplant. All patients received proton pump inhibitors (PPIs) for 100 days per protocol. After a median follow up of 5 (range 1-8.1) years for 339 evaluate transplants, 64% of patients received ABM for peptic ulcer disease (n = 28), GERD (n = 50), dyspepsia/gastritis (n = 30), recurrent liver cirrhosis (n = 15) and prophylaxis if patients were maintained on steroids (n = 21), MMF (n = 17), Sirolimus (n = 9) or received biphosphonates for osteoporosis (n = 22). In a minority of cases no clear indication could be found. Conclusions: Upper GI diseases are common complications after LT and many LT recipients require long term ABM.

Original languageEnglish (US)
Pages (from-to)57-60
Number of pages4
JournalEuropean Surgery - Acta Chirurgica Austriaca
Volume39
Issue number1
DOIs
StatePublished - May 18 2007

Keywords

  • GERD
  • Liver transplantation
  • Peptic ulcer
  • Proton pump inhibitor

ASJC Scopus subject areas

  • Surgery

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