Acid-Base and Electrolyte Managements in Chronic Kidney Disease and End-Stage Renal Disease: Case-Based Discussion

Jing Lin, Zhen Cheng, Xiaoqiang Ding, Qi Qian

Research output: Contribution to journalArticle

2 Scopus citations


Acid-base and electrolyte alterations are common in patients with chronic kidney disease (CKD) and end-stage kidney failure (ESRD). The alterations become more complex as CKD advances to ESRD, leading to morbidity and mortality. Three cases are presented illustrating some key prototypic features in CKD and ESRD. Each is accompanied by discussion of pathophysiology, diagnosis, and treatment options. Newer investigational results are integrated into the existing body of knowledge. Although rigorous assessment of various dialysis prescriptions is scanty, in its current state, instituting a well thought-out, multi-pronged management plan to minimize CKD/ESRD and dialysis-related electrolyte and acid-base disruptions is appropriate. There is a pressing need for prospective interventional trials in the future.

Original languageEnglish (US)
Pages (from-to)179-186
Number of pages8
JournalBlood Purification
Issue number1-3
StatePublished - Apr 1 2018



  • Chronic kidney disease
  • End-stage renal disease
  • Hemodialysis
  • Hypoxia
  • Metabolic acidosis
  • Metabolic alkalosis

ASJC Scopus subject areas

  • Hematology
  • Nephrology

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