Accurate transferable model for water, n-octanol, and n-hexadecane solvation free energies

A. J. Bordner, C. N. Cavasotto, R. A. Abagyan

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Abstract

We present a fast continuum method for the calculation of solvation free energies. It is based on a continuum electrostatics model with MMFF94 atomic charges combined with a nonelectrostatic term, which is a linear function of the solvent-accessible surface area. The model's parameters have been optimized using sets of 410, 382, and 2116 molecules for gas-water, gas-hexadecane, and water-octanol transfer, respectively. These are the largest, most diverse sets of molecules used to date for a similar solvation model. The model's predictive power was verified by using 90% of the molecule set for training and the remainder as a test set. The average test set errors differed by only about 1% from the average training set error, thus demonstrating the transferability of the parameters. The root-mean-square error for gas-water, gas-hexadecane, and water-octanol transfer are 0.53, 0.38, and 0.58 log P units, respectively. Because the solvation calculation takes on average only about 0.34 s per molecule on a 700 MHz Pentium CPU and contains atom types for essentially all drug molecules, it is suitable for real-time calculations of the ADME properties of molecules in virtual ligand screening libraries.

Original languageEnglish (US)
Pages (from-to)11009-11015
Number of pages7
JournalJournal of Physical Chemistry B
Volume106
Issue number42
DOIs
StatePublished - Oct 24 2002

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ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films
  • Materials Chemistry

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