Accuracy of grading gliomas on CT-guided stereotactic biopsies

A survival analysis

P. B. Gaudin, Mark E. Sherman, D. J. Brat, M. Zahurak, Y. S. Erozan

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The accuracy of using a combination of cytopathologic and histopathologic techniques to diagnose stereotactically guided brain biopsies was investigated in 74 patients. Diagnostic accuracy was assessed by determining whether classification of the biopsies as gliosis, astrocytoma (A), anaplastic astrocytoma (AA), or glioblastoma multiforme (GBM) predicted survival The utility of on-site evaluation using Diff-Quik-stained crush preparations was also assessed. The patients ranged in age from 5 to 88 years (mean, 55 years) and were followed for over 2 years in most cases. Four cases (5%) were classified as gliosis (G), 7 (9%) as atypical gliosis (AG), 4 (5%) as high-grade mixed oligodendroglioma/astrocytoma (OA), 11 (15%) as astrocytoma (A), 21 (28%) as anaplastic astrocytoma (AA), and 27 (36%) as glioblastoma multiforme (GBM). Median survival was 11 months in patient with OA, 57 months in patients with A, 10 months in patients with AA, and 5 months in patients with GBM. Diagnosis of Diff-Quik-stained crush preparations made during the biopsy procedure was highly correlated with the final diagnosis and survival. We conclude that the diagnosis of stereotactic brain biopsies using cytopathology with on-site evaluation in combination with histopathological evaluation of needle cores is accurate based on a survival analysis. However, A and G may be difficult to distinguish.

Original languageEnglish (US)
Pages (from-to)461-466
Number of pages6
JournalDiagnostic Cytopathology
Volume17
Issue number6
DOIs
StatePublished - 1997
Externally publishedYes

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Astrocytoma
Survival Analysis
Glioma
Biopsy
Gliosis
Glioblastoma
Oligodendroglioma
Survival
Brain
Needles

Keywords

  • Aspiration
  • Brain
  • Cytopathology
  • Glioma
  • Grading
  • Needle biopsy
  • Prognosis
  • Stereotactic
  • Survival

ASJC Scopus subject areas

  • Anatomy

Cite this

Accuracy of grading gliomas on CT-guided stereotactic biopsies : A survival analysis. / Gaudin, P. B.; Sherman, Mark E.; Brat, D. J.; Zahurak, M.; Erozan, Y. S.

In: Diagnostic Cytopathology, Vol. 17, No. 6, 1997, p. 461-466.

Research output: Contribution to journalArticle

Gaudin, P. B. ; Sherman, Mark E. ; Brat, D. J. ; Zahurak, M. ; Erozan, Y. S. / Accuracy of grading gliomas on CT-guided stereotactic biopsies : A survival analysis. In: Diagnostic Cytopathology. 1997 ; Vol. 17, No. 6. pp. 461-466.
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