Accuracy of fetal lung volume assessed by three-dimensional sonography

Rodrigo Ruano, J. Martinovic, M. Dommergues, M. C. Aubry, Y. Dumez, A. Benachi

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Objective: To determine the accuracy and precision of prenatal three-dimensional (3D) ultrasound in estimating fetal lung volume using the rotational multiplanar technique (VOCAL™) by comparing it to postmortem volume measurements. Methods: Fetal lung volume was measured during 3D ultrasound examination using a rotational multiplanar technique in eight cases of congenital diaphragmatic hernia (CDH) (six left and two right-sided) and in 25 controls without pulmonary malformation, immediately before termination. Prenatal 3D sonographic estimates of fetal lung volume were compared with postmortem measurement of fetal lung volume achieved by water displacement. Results: The intraclass correlation coefficient of fetal lung volume estimated by 3D ultrasound and measured at postmortem examination was 0.95 in CDH cases and 0.99 in controls. Based on Bland-Altman analysis, the bias, precision and limits of agreement were, respectively, 0.35 cm3, 1.46 cm3 and between -2.51 and +3.21 cm3 in cases with CDH and 0.08 cm 3, 2.80 cm3 and between -5.41 and +5.57 cm3 in controls. The mean relative error of 3D ultrasound fetal lung volume measurement was -7.19% (from -42.70% to +18.11%) in CDH cases and -0.72% (from -30.25% to +19.22%) in controls, while the mean absolute error of 3D ultrasound fetal lung volume measurement was 1.40 (range, 0.71-2.52) cm3 and 2.12 (range, 0.05-4.98) cm3, respectively. Accuracy of 3D ultrasound for measuring fetal lung volumes was 84.86 (range, 57.30-99.48)% in cases with CDH and 91.38 (range, 69.75-99.45)% in controls. The mean intraobserver variability for lung volume estimated by 3D ultrasound was 0.28 cm3 in controls and 0.17 cm3 in CDH cases. Conclusion: Prenatal 3D ultrasound can estimate accurately fetal lung volume using the rotational multiplanar technique for volume measurements (VOCAL), even in fetuses with very small lungs, such as cases with isolated CDH.

Original languageEnglish (US)
Pages (from-to)725-730
Number of pages6
JournalUltrasound in Obstetrics and Gynecology
Volume26
Issue number7
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

Fingerprint

Ultrasonography
Lung
Lung Volume Measurements
Observer Variation
Congenital Diaphragmatic Hernias
Autopsy
Fetus
Water

Keywords

  • Congenital diaphragmatic hernia
  • Fetal lung
  • Prenatal diagnosis
  • Three-dimensional ultrasound

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynecology

Cite this

Ruano, R., Martinovic, J., Dommergues, M., Aubry, M. C., Dumez, Y., & Benachi, A. (2005). Accuracy of fetal lung volume assessed by three-dimensional sonography. Ultrasound in Obstetrics and Gynecology, 26(7), 725-730. https://doi.org/10.1002/uog.2624

Accuracy of fetal lung volume assessed by three-dimensional sonography. / Ruano, Rodrigo; Martinovic, J.; Dommergues, M.; Aubry, M. C.; Dumez, Y.; Benachi, A.

In: Ultrasound in Obstetrics and Gynecology, Vol. 26, No. 7, 01.12.2005, p. 725-730.

Research output: Contribution to journalArticle

Ruano, R, Martinovic, J, Dommergues, M, Aubry, MC, Dumez, Y & Benachi, A 2005, 'Accuracy of fetal lung volume assessed by three-dimensional sonography', Ultrasound in Obstetrics and Gynecology, vol. 26, no. 7, pp. 725-730. https://doi.org/10.1002/uog.2624
Ruano, Rodrigo ; Martinovic, J. ; Dommergues, M. ; Aubry, M. C. ; Dumez, Y. ; Benachi, A. / Accuracy of fetal lung volume assessed by three-dimensional sonography. In: Ultrasound in Obstetrics and Gynecology. 2005 ; Vol. 26, No. 7. pp. 725-730.
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abstract = "Objective: To determine the accuracy and precision of prenatal three-dimensional (3D) ultrasound in estimating fetal lung volume using the rotational multiplanar technique (VOCAL™) by comparing it to postmortem volume measurements. Methods: Fetal lung volume was measured during 3D ultrasound examination using a rotational multiplanar technique in eight cases of congenital diaphragmatic hernia (CDH) (six left and two right-sided) and in 25 controls without pulmonary malformation, immediately before termination. Prenatal 3D sonographic estimates of fetal lung volume were compared with postmortem measurement of fetal lung volume achieved by water displacement. Results: The intraclass correlation coefficient of fetal lung volume estimated by 3D ultrasound and measured at postmortem examination was 0.95 in CDH cases and 0.99 in controls. Based on Bland-Altman analysis, the bias, precision and limits of agreement were, respectively, 0.35 cm3, 1.46 cm3 and between -2.51 and +3.21 cm3 in cases with CDH and 0.08 cm 3, 2.80 cm3 and between -5.41 and +5.57 cm3 in controls. The mean relative error of 3D ultrasound fetal lung volume measurement was -7.19{\%} (from -42.70{\%} to +18.11{\%}) in CDH cases and -0.72{\%} (from -30.25{\%} to +19.22{\%}) in controls, while the mean absolute error of 3D ultrasound fetal lung volume measurement was 1.40 (range, 0.71-2.52) cm3 and 2.12 (range, 0.05-4.98) cm3, respectively. Accuracy of 3D ultrasound for measuring fetal lung volumes was 84.86 (range, 57.30-99.48){\%} in cases with CDH and 91.38 (range, 69.75-99.45){\%} in controls. The mean intraobserver variability for lung volume estimated by 3D ultrasound was 0.28 cm3 in controls and 0.17 cm3 in CDH cases. Conclusion: Prenatal 3D ultrasound can estimate accurately fetal lung volume using the rotational multiplanar technique for volume measurements (VOCAL), even in fetuses with very small lungs, such as cases with isolated CDH.",
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AU - Martinovic, J.

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AU - Dumez, Y.

AU - Benachi, A.

PY - 2005/12/1

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N2 - Objective: To determine the accuracy and precision of prenatal three-dimensional (3D) ultrasound in estimating fetal lung volume using the rotational multiplanar technique (VOCAL™) by comparing it to postmortem volume measurements. Methods: Fetal lung volume was measured during 3D ultrasound examination using a rotational multiplanar technique in eight cases of congenital diaphragmatic hernia (CDH) (six left and two right-sided) and in 25 controls without pulmonary malformation, immediately before termination. Prenatal 3D sonographic estimates of fetal lung volume were compared with postmortem measurement of fetal lung volume achieved by water displacement. Results: The intraclass correlation coefficient of fetal lung volume estimated by 3D ultrasound and measured at postmortem examination was 0.95 in CDH cases and 0.99 in controls. Based on Bland-Altman analysis, the bias, precision and limits of agreement were, respectively, 0.35 cm3, 1.46 cm3 and between -2.51 and +3.21 cm3 in cases with CDH and 0.08 cm 3, 2.80 cm3 and between -5.41 and +5.57 cm3 in controls. The mean relative error of 3D ultrasound fetal lung volume measurement was -7.19% (from -42.70% to +18.11%) in CDH cases and -0.72% (from -30.25% to +19.22%) in controls, while the mean absolute error of 3D ultrasound fetal lung volume measurement was 1.40 (range, 0.71-2.52) cm3 and 2.12 (range, 0.05-4.98) cm3, respectively. Accuracy of 3D ultrasound for measuring fetal lung volumes was 84.86 (range, 57.30-99.48)% in cases with CDH and 91.38 (range, 69.75-99.45)% in controls. The mean intraobserver variability for lung volume estimated by 3D ultrasound was 0.28 cm3 in controls and 0.17 cm3 in CDH cases. Conclusion: Prenatal 3D ultrasound can estimate accurately fetal lung volume using the rotational multiplanar technique for volume measurements (VOCAL), even in fetuses with very small lungs, such as cases with isolated CDH.

AB - Objective: To determine the accuracy and precision of prenatal three-dimensional (3D) ultrasound in estimating fetal lung volume using the rotational multiplanar technique (VOCAL™) by comparing it to postmortem volume measurements. Methods: Fetal lung volume was measured during 3D ultrasound examination using a rotational multiplanar technique in eight cases of congenital diaphragmatic hernia (CDH) (six left and two right-sided) and in 25 controls without pulmonary malformation, immediately before termination. Prenatal 3D sonographic estimates of fetal lung volume were compared with postmortem measurement of fetal lung volume achieved by water displacement. Results: The intraclass correlation coefficient of fetal lung volume estimated by 3D ultrasound and measured at postmortem examination was 0.95 in CDH cases and 0.99 in controls. Based on Bland-Altman analysis, the bias, precision and limits of agreement were, respectively, 0.35 cm3, 1.46 cm3 and between -2.51 and +3.21 cm3 in cases with CDH and 0.08 cm 3, 2.80 cm3 and between -5.41 and +5.57 cm3 in controls. The mean relative error of 3D ultrasound fetal lung volume measurement was -7.19% (from -42.70% to +18.11%) in CDH cases and -0.72% (from -30.25% to +19.22%) in controls, while the mean absolute error of 3D ultrasound fetal lung volume measurement was 1.40 (range, 0.71-2.52) cm3 and 2.12 (range, 0.05-4.98) cm3, respectively. Accuracy of 3D ultrasound for measuring fetal lung volumes was 84.86 (range, 57.30-99.48)% in cases with CDH and 91.38 (range, 69.75-99.45)% in controls. The mean intraobserver variability for lung volume estimated by 3D ultrasound was 0.28 cm3 in controls and 0.17 cm3 in CDH cases. Conclusion: Prenatal 3D ultrasound can estimate accurately fetal lung volume using the rotational multiplanar technique for volume measurements (VOCAL), even in fetuses with very small lungs, such as cases with isolated CDH.

KW - Congenital diaphragmatic hernia

KW - Fetal lung

KW - Prenatal diagnosis

KW - Three-dimensional ultrasound

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