Accuracy of CT colonography for detection of large adenomas and cancers

C. Daniel Johnson, Mei Hsiu Chen, Alicia Y. Toledano, Jay Heiken, Abraham Dachman, Mark D. Kuo, Christine O. Menias, Betina Siewert, Jugesh I. Cheema, Richard G. Obregon, Jeff L. Fidler, Peter Zimmerman, Karen M. Horton, Kevin Coakley, Revathy B. Iyer, Amy K. Hara, Robert A. Halvorsen, Giovanna Casola, Judy Yee, Benjamin A. HermanLawrence J. Burgart, Paul John Limburg

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783 Scopus citations

Abstract

BACKGROUND: Computed tomographic (CT) colonography is a noninvasive option in screening for colorectal cancer. However, its accuracy as a screening tool in asymptomatic adults has not been well defined. METHODS: We recruited 2600 asymptomatic study participants, 50 years of age or older, at 15 study centers. CT colonographic images were acquired with the use of standard bowel preparation, stool and fluid tagging, mechanical insufflation, and multidetector-row CT scanners (with 16 or more rows). Radiologists trained in CT colonography reported all lesions measuring 5 mm or more in diameter. Optical colonoscopy and histologic review were performed according to established clinical protocols at each center and served as the reference standard. The primary end point was detection by CT colonography of histologically confirmed large adenomas and adenocarcinomas (10 mm in diameter or larger) that had been detected by colonoscopy; detection of smaller colorectal lesions (6 to 9 mm in diameter) was also evaluated. RESULTS: Complete data were available for 2531 participants (97%). For large adenomas and cancers, the mean (±SE) per-patient estimates of the sensitivity, specificity, positive and negative predictive values, and area under the receiver-operating-characteristic curve for CT colonography were 0.90±0.03, 0.86±0.02, 0.23±0.02, 0.99±<0.01, and 0.89±0.02, respectively. The sensitivity of 0.90 (i.e., 90%) indicates that CT colonography failed to detect a lesion measuring 10 mm or more in diameter in 10% of patients. The per-polyp sensitivity for large adenomas or cancers was 0.84±0.04. The per-patient sensitivity for detecting adenomas that were 6 mm or more in diameter was 0.78. CONCLUSIONS: In this study of asymptomatic adults, CT colonographic screening identified 90% of subjects with adenomas or cancers measuring 10 mm or more in diameter. These findings augment published data on the role of CT colonography in screening patients with an average risk of colorectal cancer. (ClinicalTrials.gov number, NCT00084929; American College of Radiology Imaging Network [ACRIN] number, 6664.)

Original languageEnglish (US)
Pages (from-to)1207-1217
Number of pages11
JournalNew England Journal of Medicine
Volume359
Issue number12
DOIs
StatePublished - Sep 18 2008

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ASJC Scopus subject areas

  • Medicine(all)

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Johnson, C. D., Chen, M. H., Toledano, A. Y., Heiken, J., Dachman, A., Kuo, M. D., Menias, C. O., Siewert, B., Cheema, J. I., Obregon, R. G., Fidler, J. L., Zimmerman, P., Horton, K. M., Coakley, K., Iyer, R. B., Hara, A. K., Halvorsen, R. A., Casola, G., Yee, J., ... Limburg, P. J. (2008). Accuracy of CT colonography for detection of large adenomas and cancers. New England Journal of Medicine, 359(12), 1207-1217. https://doi.org/10.1056/NEJMoa0800996