Accuracy of chemical shift MR imaging in diagnosing indeterminate bone marrow lesions in the pelvis: Review of a single institution's experience

Chad A. Kohl, F. Spencer Chivers, Roxanne Lorans, Catherine C. Roberts, Mark J. Kransdorf

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: To re-assess the accuracy of chemical shift imaging in diagnosing indeterminate bone marrow lesions as benign or malignant. Materials and methods: We retrospectively reviewed our experience with MR imaging of the pelvis to assess the accuracy of chemical shift imaging in distinguishing benign from malignant bone lesions. Two musculoskeletal radiologists retrospectively reviewed all osseous lesions biopsied since 2006, when chemical shift imaging was added to our routine pelvic imaging protocol. Study inclusion criteria required (1) MR imaging of an indeterminate bone marrow lesion about the pelvis and (2) subsequent histologic confirmation. The study group included 50 patients (29 male, 21 female) with an average age of 67 years (range, 41-89 years). MR imaging results were evaluated using biopsy results as the "gold standard." Results: There were 27 malignant and 23 benign lesions. Chemical shift imaging using an opposed-phase signal loss criteria of less than 20 % to indicate a malignant lesion, correctly diagnosed 27/27 malignant lesions and 14/23 benign lesions, yielding a 100 % sensitivity, 61 % specificity, 75 % PPV, 100 % NPV, and 82 % accuracy. The area under the receiver operator characteristic (ROC) curve was 0.88. The inter-rater and intra-rater agreement K values were both 1.0. Conclusions: Chemical shift imaging is a useful adjunct MR technique to characterize focal and diffuse marrow abnormalities on routine non-contrast pelvic imaging. It is highly sensitive in identifying malignant disease. Despite its lower specificity, the need for biopsy could be eliminated in more than 60 % of patients with benign disease.

Original languageEnglish (US)
Pages (from-to)1079-1084
Number of pages6
JournalSkeletal Radiology
Volume43
Issue number8
DOIs
StatePublished - 2014

Fingerprint

Pelvis
Bone Marrow
Magnetic Resonance Imaging
Biopsy
Bone and Bones
Sensitivity and Specificity

Keywords

  • Bone marrow lesion
  • Chemical shift
  • In- and opposed-phase
  • MR imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Accuracy of chemical shift MR imaging in diagnosing indeterminate bone marrow lesions in the pelvis : Review of a single institution's experience. / Kohl, Chad A.; Chivers, F. Spencer; Lorans, Roxanne; Roberts, Catherine C.; Kransdorf, Mark J.

In: Skeletal Radiology, Vol. 43, No. 8, 2014, p. 1079-1084.

Research output: Contribution to journalArticle

Kohl, Chad A. ; Chivers, F. Spencer ; Lorans, Roxanne ; Roberts, Catherine C. ; Kransdorf, Mark J. / Accuracy of chemical shift MR imaging in diagnosing indeterminate bone marrow lesions in the pelvis : Review of a single institution's experience. In: Skeletal Radiology. 2014 ; Vol. 43, No. 8. pp. 1079-1084.
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