ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: A report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents

Deepak L. Bhatt; James Scheiman; Neena S. Abraham; Elliott M. Antman; Francis K.L. Chan; Curt D. Furberg; David A. Johnson; Kenneth W. Mahaffey; Eamonn M. Quigley; Robert A. Harrington; Eric R. Bates; Charles R. Bridges; Mark J. Eisenberg; Victor A. Ferrari; Mark A. Hlatky; Sanjay Kaul; Jonathan R. Lindner; David J. Moliterno; Debabrata Mukherjee; Richard S. Schofield; Robert S. Rosenson; James H. Stein; Howard H. Weitz; Deborah J. Wesley

doi:10.1161/CIRCULATIONAHA.108.191087

ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: A report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents

Deepak L. Bhatt, James Scheiman, Neena S. Abraham, Elliott M. Antman, Francis K.L. Chan, Curt D. Furberg, David A. Johnson, Kenneth W. Mahaffey, Eamonn M. Quigley, Robert A. Harrington, Eric R. Bates, Charles R. Bridges, Mark J. Eisenberg, Victor A. Ferrari, Mark A. Hlatky, Sanjay Kaul, Jonathan R. Lindner, David J. Moliterno, Debabrata Mukherjee, Richard S. SchofieldRobert S. Rosenson, James H. Stein, Howard H. Weitz, Deborah J. Wesley

Research output: Contribution to journal › Article › peer-review

393 Scopus citations

Abstract

In appropriate patients, oral antiplatelet therapy decreases ischemic risks, but this therapy may increase bleeding complications. Of the major bleeding that occurs, the largest proportion is due to GI hemorrhage. Concomitant use of NSAIDs further raises the risk of GI bleeding. Gastroprotection strategies consist of use of PPIs in patients at high risk of GI bleeding and eradication of H pylori in patients with a history of ulcers. Communication between cardiologists, gastroenterologists, and primary care physicians is critical to weigh the ischemic and bleeding risks in an individual patient who needs antiplatelet therapy but who is at risk for or develops significant GI bleeding.

Original language	English (US)
Pages (from-to)	1894-1909
Number of pages	16
Journal	Circulation
Volume	118
Issue number	18
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.108.191087
State	Published - Oct 28 2008

Keywords

AHA Scientific Statements
Antiplatelet therapy
Aspirin
Gastroduodenal ulcer
Gastrointestinal bleeding
Gastrointestinal risk
NSAID
Stents
Thrombosis

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Physiology (medical)

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Bhatt, D. L., Scheiman, J., Abraham, N. S., Antman, E. M., Chan, F. K. L., Furberg, C. D., Johnson, D. A., Mahaffey, K. W., Quigley, E. M., Harrington, R. A., Bates, E. R., Bridges, C. R., Eisenberg, M. J., Ferrari, V. A., Hlatky, M. A., Kaul, S., Lindner, J. R., Moliterno, D. J., Mukherjee, D., ... Wesley, D. J. (2008). ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: A report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents. Circulation, 118(18), 1894-1909. https://doi.org/10.1161/CIRCULATIONAHA.108.191087

ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: A report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents. / Bhatt, Deepak L.; Scheiman, James; Abraham, Neena S. et al.
In: Circulation, Vol. 118, No. 18, 28.10.2008, p. 1894-1909.

Research output: Contribution to journal › Article › peer-review

Bhatt, DL, Scheiman, J, Abraham, NS, Antman, EM, Chan, FKL, Furberg, CD, Johnson, DA, Mahaffey, KW, Quigley, EM, Harrington, RA, Bates, ER, Bridges, CR, Eisenberg, MJ, Ferrari, VA, Hlatky, MA, Kaul, S, Lindner, JR, Moliterno, DJ, Mukherjee, D, Schofield, RS, Rosenson, RS, Stein, JH, Weitz, HH & Wesley, DJ 2008, 'ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: A report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents', Circulation, vol. 118, no. 18, pp. 1894-1909. https://doi.org/10.1161/CIRCULATIONAHA.108.191087

Bhatt DL, Scheiman J, Abraham NS, Antman EM, Chan FKL, Furberg CD et al. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: A report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents. Circulation. 2008 Oct 28;118(18):1894-1909. doi: 10.1161/CIRCULATIONAHA.108.191087

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abstract = "In appropriate patients, oral antiplatelet therapy decreases ischemic risks, but this therapy may increase bleeding complications. Of the major bleeding that occurs, the largest proportion is due to GI hemorrhage. Concomitant use of NSAIDs further raises the risk of GI bleeding. Gastroprotection strategies consist of use of PPIs in patients at high risk of GI bleeding and eradication of H pylori in patients with a history of ulcers. Communication between cardiologists, gastroenterologists, and primary care physicians is critical to weigh the ischemic and bleeding risks in an individual patient who needs antiplatelet therapy but who is at risk for or develops significant GI bleeding.",

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ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: A report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents

Abstract

Keywords

ASJC Scopus subject areas

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