Accelerated vs. unaccelerated serial MRI based TBM-SyN measurements for clinical trials in Alzheimer's disease

Alzheimer's Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: Our primary objective was to compare the performance of unaccelerated vs. accelerated structural MRI for measuring disease progression using serial scans in Alzheimer's disease (AD). Methods: We identified cognitively normal (CN), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI) and AD subjects from all available Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects with usable pairs of accelerated and unaccelerated scans. There were a total of 696 subjects with baseline and 3. month scans, 628 subjects with baseline and 6. month scans and 464 subjects with baseline and 12. month scans available. We employed the Symmetric Diffeomorphic Image Normalization method (SyN) for normalization of the serial scans to obtain tensor based morphometry (TBM) maps which indicate the structural changes between pairs of scans. We computed a TBM-SyN summary score of annualized structural changes over 31 regions of interest (ROIs) that are characteristically affected in AD. TBM-SyN scores were computed using accelerated and unaccelerated scan pairs and compared in terms of agreement, group-wise discrimination, and sample size estimates for a hypothetical therapeutic trial. Results: We observed a number of systematic differences between TBM-SyN scores computed from accelerated and unaccelerated pairs of scans. TBM-SyN scores computed from accelerated scans tended to have overall higher estimated values than those from unaccelerated scans. However, the performance of accelerated scans was comparable to unaccelerated scans in terms of discrimination between clinical groups and sample sizes required in each clinical group for a therapeutic trial. We also found that the quality of both accelerated vs. unaccelerated scans were similar. Conclusions: Accelerated scanning protocols reduce scan time considerably. Their group-wise discrimination and sample size estimates were comparable to those obtained with unaccelerated scans. The two protocols did not produce interchangeable TBM-SyN estimates, so it is arguably important to use either accelerated pairs of scans or unaccelerated pairs of scans throughout the study duration.

Original languageEnglish (US)
Pages (from-to)61-69
Number of pages9
JournalNeuroImage
Volume113
DOIs
StatePublished - Jun 1 2015

Fingerprint

Alzheimer Disease
Clinical Trials
Sample Size
Neuroimaging
Disease Progression
Therapeutics
Cognitive Dysfunction

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Accelerated vs. unaccelerated serial MRI based TBM-SyN measurements for clinical trials in Alzheimer's disease. / Alzheimer's Disease Neuroimaging Initiative.

In: NeuroImage, Vol. 113, 01.06.2015, p. 61-69.

Research output: Contribution to journalArticle

Alzheimer's Disease Neuroimaging Initiative. / Accelerated vs. unaccelerated serial MRI based TBM-SyN measurements for clinical trials in Alzheimer's disease. In: NeuroImage. 2015 ; Vol. 113. pp. 61-69.
@article{91f86e711b92442d9cd781f01e4d262a,
title = "Accelerated vs. unaccelerated serial MRI based TBM-SyN measurements for clinical trials in Alzheimer's disease",
abstract = "Objective: Our primary objective was to compare the performance of unaccelerated vs. accelerated structural MRI for measuring disease progression using serial scans in Alzheimer's disease (AD). Methods: We identified cognitively normal (CN), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI) and AD subjects from all available Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects with usable pairs of accelerated and unaccelerated scans. There were a total of 696 subjects with baseline and 3. month scans, 628 subjects with baseline and 6. month scans and 464 subjects with baseline and 12. month scans available. We employed the Symmetric Diffeomorphic Image Normalization method (SyN) for normalization of the serial scans to obtain tensor based morphometry (TBM) maps which indicate the structural changes between pairs of scans. We computed a TBM-SyN summary score of annualized structural changes over 31 regions of interest (ROIs) that are characteristically affected in AD. TBM-SyN scores were computed using accelerated and unaccelerated scan pairs and compared in terms of agreement, group-wise discrimination, and sample size estimates for a hypothetical therapeutic trial. Results: We observed a number of systematic differences between TBM-SyN scores computed from accelerated and unaccelerated pairs of scans. TBM-SyN scores computed from accelerated scans tended to have overall higher estimated values than those from unaccelerated scans. However, the performance of accelerated scans was comparable to unaccelerated scans in terms of discrimination between clinical groups and sample sizes required in each clinical group for a therapeutic trial. We also found that the quality of both accelerated vs. unaccelerated scans were similar. Conclusions: Accelerated scanning protocols reduce scan time considerably. Their group-wise discrimination and sample size estimates were comparable to those obtained with unaccelerated scans. The two protocols did not produce interchangeable TBM-SyN estimates, so it is arguably important to use either accelerated pairs of scans or unaccelerated pairs of scans throughout the study duration.",
author = "{Alzheimer's Disease Neuroimaging Initiative} and Vemuri, {Prashanthi D} and Senjem, {Matthew L.} and Gunter, {Jeffrey L.} and Lundt, {Emily S.} and Nirubol Tosakulwong and Weigand, {Stephen D.} and Borowski, {Bret J.} and Bernstein, {Matthew A} and Zuk, {Samantha M.} and Val Lowe and Knopman, {David S} and Petersen, {Ronald Carl} and Fox, {Nick C.} and Thompson, {Paul M.} and Weiner, {Michael W.} and Jack, {Clifford R Jr.}",
year = "2015",
month = "6",
day = "1",
doi = "10.1016/j.neuroimage.2015.03.026",
language = "English (US)",
volume = "113",
pages = "61--69",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Accelerated vs. unaccelerated serial MRI based TBM-SyN measurements for clinical trials in Alzheimer's disease

AU - Alzheimer's Disease Neuroimaging Initiative

AU - Vemuri, Prashanthi D

AU - Senjem, Matthew L.

AU - Gunter, Jeffrey L.

AU - Lundt, Emily S.

AU - Tosakulwong, Nirubol

AU - Weigand, Stephen D.

AU - Borowski, Bret J.

AU - Bernstein, Matthew A

AU - Zuk, Samantha M.

AU - Lowe, Val

AU - Knopman, David S

AU - Petersen, Ronald Carl

AU - Fox, Nick C.

AU - Thompson, Paul M.

AU - Weiner, Michael W.

AU - Jack, Clifford R Jr.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Objective: Our primary objective was to compare the performance of unaccelerated vs. accelerated structural MRI for measuring disease progression using serial scans in Alzheimer's disease (AD). Methods: We identified cognitively normal (CN), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI) and AD subjects from all available Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects with usable pairs of accelerated and unaccelerated scans. There were a total of 696 subjects with baseline and 3. month scans, 628 subjects with baseline and 6. month scans and 464 subjects with baseline and 12. month scans available. We employed the Symmetric Diffeomorphic Image Normalization method (SyN) for normalization of the serial scans to obtain tensor based morphometry (TBM) maps which indicate the structural changes between pairs of scans. We computed a TBM-SyN summary score of annualized structural changes over 31 regions of interest (ROIs) that are characteristically affected in AD. TBM-SyN scores were computed using accelerated and unaccelerated scan pairs and compared in terms of agreement, group-wise discrimination, and sample size estimates for a hypothetical therapeutic trial. Results: We observed a number of systematic differences between TBM-SyN scores computed from accelerated and unaccelerated pairs of scans. TBM-SyN scores computed from accelerated scans tended to have overall higher estimated values than those from unaccelerated scans. However, the performance of accelerated scans was comparable to unaccelerated scans in terms of discrimination between clinical groups and sample sizes required in each clinical group for a therapeutic trial. We also found that the quality of both accelerated vs. unaccelerated scans were similar. Conclusions: Accelerated scanning protocols reduce scan time considerably. Their group-wise discrimination and sample size estimates were comparable to those obtained with unaccelerated scans. The two protocols did not produce interchangeable TBM-SyN estimates, so it is arguably important to use either accelerated pairs of scans or unaccelerated pairs of scans throughout the study duration.

AB - Objective: Our primary objective was to compare the performance of unaccelerated vs. accelerated structural MRI for measuring disease progression using serial scans in Alzheimer's disease (AD). Methods: We identified cognitively normal (CN), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI) and AD subjects from all available Alzheimer's Disease Neuroimaging Initiative (ADNI) subjects with usable pairs of accelerated and unaccelerated scans. There were a total of 696 subjects with baseline and 3. month scans, 628 subjects with baseline and 6. month scans and 464 subjects with baseline and 12. month scans available. We employed the Symmetric Diffeomorphic Image Normalization method (SyN) for normalization of the serial scans to obtain tensor based morphometry (TBM) maps which indicate the structural changes between pairs of scans. We computed a TBM-SyN summary score of annualized structural changes over 31 regions of interest (ROIs) that are characteristically affected in AD. TBM-SyN scores were computed using accelerated and unaccelerated scan pairs and compared in terms of agreement, group-wise discrimination, and sample size estimates for a hypothetical therapeutic trial. Results: We observed a number of systematic differences between TBM-SyN scores computed from accelerated and unaccelerated pairs of scans. TBM-SyN scores computed from accelerated scans tended to have overall higher estimated values than those from unaccelerated scans. However, the performance of accelerated scans was comparable to unaccelerated scans in terms of discrimination between clinical groups and sample sizes required in each clinical group for a therapeutic trial. We also found that the quality of both accelerated vs. unaccelerated scans were similar. Conclusions: Accelerated scanning protocols reduce scan time considerably. Their group-wise discrimination and sample size estimates were comparable to those obtained with unaccelerated scans. The two protocols did not produce interchangeable TBM-SyN estimates, so it is arguably important to use either accelerated pairs of scans or unaccelerated pairs of scans throughout the study duration.

UR - http://www.scopus.com/inward/record.url?scp=84925871316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925871316&partnerID=8YFLogxK

U2 - 10.1016/j.neuroimage.2015.03.026

DO - 10.1016/j.neuroimage.2015.03.026

M3 - Article

C2 - 25797830

AN - SCOPUS:84925871316

VL - 113

SP - 61

EP - 69

JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

ER -