Absolute monocyte/lymphocyte count prognostic score is independent of immunohistochemically determined cell of origin in predicting survival in diffuse large B-cell lymphoma

Luis F. Porrata, Kay Ristow, Thomas Matthew Habermann, Nazan Ozsan, Ahmet Dogan, William MacOn, Joseph P. Colgan, Thomas Elmer Witzig, David J. Inwards, Stephen Maxted Ansell, Ivana Micallef, Patrick Bruce Johnston, Grzegorz S Nowakowski, Carrie A Thompson, Svetomir Nenad Markovic

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Abstract

The absolute monocyte/lymphocyte count prognostic score (AMC/ALC score) has not been directly compared with the cell of origin (COO) to predict overall survival (OS) and progression-free survival (PFS) in diffuse large B-cell lymphoma (DLBCL). Thus, we retrospectively examined a new cohort of 99 patients with DLBCL treated from 2008 to 2010, (1) to validate whether AMC/ALC score affects survival, (2) to investigate whether AMC/ALC score is independent of COO to predict survival and (3) to assess whether AMC/ALC score can further stratify clinical outcomes by COO. By univariate analysis, the AMC/ALC score was a predictor for OS and PFS. On multivariate analysis performed including the COO and the International Prognostic Index, AMC/ALC score remained an independent predictor for OS and PFS. The AMC/ALC score was able to further stratify DLBCL clinical outcomes by COO. The AMC/ALC score was independent of COO and added to its ability to identify patients with high-risk disease.

Original languageEnglish (US)
Pages (from-to)2159-2165
Number of pages7
JournalLeukemia and Lymphoma
Volume53
Issue number11
DOIs
StatePublished - Nov 2012

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Lymphoma, Large B-Cell, Diffuse
Lymphocyte Count
Monocytes
Survival
Disease-Free Survival
Multivariate Analysis

Keywords

  • Lymphoma and Hodgkin disease
  • monocyte/lymphocyte prognostic score
  • survival

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

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title = "Absolute monocyte/lymphocyte count prognostic score is independent of immunohistochemically determined cell of origin in predicting survival in diffuse large B-cell lymphoma",
abstract = "The absolute monocyte/lymphocyte count prognostic score (AMC/ALC score) has not been directly compared with the cell of origin (COO) to predict overall survival (OS) and progression-free survival (PFS) in diffuse large B-cell lymphoma (DLBCL). Thus, we retrospectively examined a new cohort of 99 patients with DLBCL treated from 2008 to 2010, (1) to validate whether AMC/ALC score affects survival, (2) to investigate whether AMC/ALC score is independent of COO to predict survival and (3) to assess whether AMC/ALC score can further stratify clinical outcomes by COO. By univariate analysis, the AMC/ALC score was a predictor for OS and PFS. On multivariate analysis performed including the COO and the International Prognostic Index, AMC/ALC score remained an independent predictor for OS and PFS. The AMC/ALC score was able to further stratify DLBCL clinical outcomes by COO. The AMC/ALC score was independent of COO and added to its ability to identify patients with high-risk disease.",
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author = "Porrata, {Luis F.} and Kay Ristow and Habermann, {Thomas Matthew} and Nazan Ozsan and Ahmet Dogan and William MacOn and Colgan, {Joseph P.} and Witzig, {Thomas Elmer} and Inwards, {David J.} and Ansell, {Stephen Maxted} and Ivana Micallef and Johnston, {Patrick Bruce} and Nowakowski, {Grzegorz S} and Thompson, {Carrie A} and Markovic, {Svetomir Nenad}",
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T1 - Absolute monocyte/lymphocyte count prognostic score is independent of immunohistochemically determined cell of origin in predicting survival in diffuse large B-cell lymphoma

AU - Porrata, Luis F.

AU - Ristow, Kay

AU - Habermann, Thomas Matthew

AU - Ozsan, Nazan

AU - Dogan, Ahmet

AU - MacOn, William

AU - Colgan, Joseph P.

AU - Witzig, Thomas Elmer

AU - Inwards, David J.

AU - Ansell, Stephen Maxted

AU - Micallef, Ivana

AU - Johnston, Patrick Bruce

AU - Nowakowski, Grzegorz S

AU - Thompson, Carrie A

AU - Markovic, Svetomir Nenad

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