Absolute lymphocyte count predicts overall survival in follicular lymphomas

Mustaqeem Siddiqui, Kay Ristow, Svetomir Nenad Markovic, Thomas Elmer Witzig, Thomas Matthew Habermann, Joseph P. Colgan, David J. Inwards, William L. White, Stephen Maxted Ansell, Ivana Micallef, Patrick Bruce Johnston, Timothy G. Call, Luis F. Porrata

Research output: Contribution to journalArticle

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Abstract

The peripheral blood absolute lymphocyte count (ALC) recovery after autologous stem cell transplantation has been shown to be an independent prognostic factor for survival for different haematologic malignancies. The role of ALC at diagnosis for follicular (grades 1 and 2) lymphomas (FL) on survival is not well described. The primary objective of this study was to assess the role of ALC on overall survival (OS) in FL patients. Of 1104 FL patients, 228 patients were originally diagnosed, followed, and had all treatment at the Mayo Clinic from 1984 and 1999, were evaluated. The median follow-up was 89 months (range: 8.35-248). ALC as a continuous variable was identified as a predictor for OS [Hazard ratio (HR) = 0.74, P < 0.04]. ALC ≥ 1.0 × 10 9/l (n = 164) predicted a longer OS versus ALC < 1.0 × 109/l (n = 64; 175 vs. 73 months respectively, P < 0.0001). When compared with the Follicular Lymphoma International Prognostic Index (FLIPI), ALC was an independent prognostic factor for OS by multivariate analysis (HR = 0.677, P < 0.0001). These data suggest a critical role of FL patients' immune status at diagnosis on survival.

Original languageEnglish (US)
Pages (from-to)596-601
Number of pages6
JournalBritish Journal of Haematology
Volume134
Issue number6
DOIs
StatePublished - Sep 2006

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Follicular Lymphoma
Lymphocyte Count
Survival
Stem Cell Transplantation
Hematologic Neoplasms
Survival Analysis
Multivariate Analysis

Keywords

  • Absolute lymphocyte count
  • Follicular (grades 1 and 2) lymphomas
  • Follicular Lymphoma International Prognostic Index
  • Survival

ASJC Scopus subject areas

  • Hematology

Cite this

Absolute lymphocyte count predicts overall survival in follicular lymphomas. / Siddiqui, Mustaqeem; Ristow, Kay; Markovic, Svetomir Nenad; Witzig, Thomas Elmer; Habermann, Thomas Matthew; Colgan, Joseph P.; Inwards, David J.; White, William L.; Ansell, Stephen Maxted; Micallef, Ivana; Johnston, Patrick Bruce; Call, Timothy G.; Porrata, Luis F.

In: British Journal of Haematology, Vol. 134, No. 6, 09.2006, p. 596-601.

Research output: Contribution to journalArticle

Siddiqui, Mustaqeem ; Ristow, Kay ; Markovic, Svetomir Nenad ; Witzig, Thomas Elmer ; Habermann, Thomas Matthew ; Colgan, Joseph P. ; Inwards, David J. ; White, William L. ; Ansell, Stephen Maxted ; Micallef, Ivana ; Johnston, Patrick Bruce ; Call, Timothy G. ; Porrata, Luis F. / Absolute lymphocyte count predicts overall survival in follicular lymphomas. In: British Journal of Haematology. 2006 ; Vol. 134, No. 6. pp. 596-601.
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