Absence of histologic retinal toxicity of intravitreal nanogold in a rabbit model

Sophie J. Bakri, Jose S. Pulido, Priyabata Mukherjee, Ronald J. Marler, Debabrata Mukhopadhyay

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

PURPOSE: To evaluate the retinal toxicity of intravitreal nanogold, a novel antiangiogenic and long-term delivery agent. METHODS: One eye of each of 16 Dutch-belted rabbits was injected with intravitreal nanogold; the other eye served as a control. Eight rabbits received a dose of 67 μmol/0.1 mL of nanogold intravitreally into 1 eye; the other 8 rabbits received a dose of 670 μmol/0.1 mL of nanogold intravitreally into 1 eye. Eight rabbits were killed at 1 week, and eight were killed at 1 month; both eyes of each rabbit were enucleated. The eyes were fixed with 2% paraformaldehyde and sectioned for histologic examination. RESULTS: In all injected and control eyes, there was mild vacuolization in the inner plexiform and ganglion cell layers. The retina and retinal pigment epithelium were otherwise histologically normal. CONCLUSION: Intravitreal nanogold at concentrations of 67 μmol/0.1 mL and 670 μmol/0.1 mL showed no signs of retinal or optic nerve toxicity by light microscopy during histologic examination at 1 month.

Original languageEnglish (US)
Pages (from-to)147-149
Number of pages3
JournalRetina
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2008

Keywords

  • Antiangiogenic
  • Eye
  • Histopathology
  • Intravitreal
  • Nanogold
  • Rabbit
  • Toxicity

ASJC Scopus subject areas

  • Ophthalmology

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