Abrogation by a potent gonadotropin-releasing hormone antagonist of the estrogen/progesteronestimulated surge-like release of luteinizing hormone and follicle-stimulating hormone in postmenopausal women

Lisa A. Kolp, Spyros N. Pavlou, Randall J. Urban, Jean C. Rivier, Wylie W. Vale, Johannes D Veldhuis

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

In both the rodent and primate, administration of progesterone elicits an acute surge-like release of LH in the setting of prior estrogen treatment. Whether these facilitative effects of estrogen and progesterone on gonadotropin secretion reside at pituitary or hypothalamic loci is not known. To further investigate the mechanisms by which estrogen comblined with progesterone amplifies gonadotropin secretion, we studied the responses of seven estrogen-primed postmenopausal women to progesterone administration with or without cotreatment with a potent GnRH antagonist, [Ac-D2Nal1,D4ClPhe2,D3Pal3,Arg 5,DGlu6(AA), DAla10]GnRH. Repetitive blood sampling for the later measurement of serum concentrations of LH, FSH, and PRL was begun 4 h before the administration of progesterone and continued for 36 h. We observed that progesterone administration after 72 h of priming with ethinyl estradiol resulted in a surge-like release of LH and FSH in all subjects. Concommitant administration of the GnRH antagonist abolished the surge-like release of both gonadotropins in all subjects. In contrast, administration of the antagonist had no effect on PRL release. These results indicate that endogenous GnRH action is an obligatory component of the progesterone-induced surge-like release of both gonado-tropic hormones in the estrogen-primed human.

Original languageEnglish (US)
Pages (from-to)993-997
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Volume75
Issue number4
StatePublished - 1992
Externally publishedYes

Fingerprint

Hormone Antagonists
Follicle Stimulating Hormone
Luteinizing Hormone
Gonadotropin-Releasing Hormone
Progesterone
Estrogens
Gonadotropins
Tropics
Ethinyl Estradiol
Primates
Rodentia
Blood
Hormones
Sampling
Serum

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Abrogation by a potent gonadotropin-releasing hormone antagonist of the estrogen/progesteronestimulated surge-like release of luteinizing hormone and follicle-stimulating hormone in postmenopausal women. / Kolp, Lisa A.; Pavlou, Spyros N.; Urban, Randall J.; Rivier, Jean C.; Vale, Wylie W.; Veldhuis, Johannes D.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 75, No. 4, 1992, p. 993-997.

Research output: Contribution to journalArticle

@article{0925c1a92ab64239a2a12d4be27db244,
title = "Abrogation by a potent gonadotropin-releasing hormone antagonist of the estrogen/progesteronestimulated surge-like release of luteinizing hormone and follicle-stimulating hormone in postmenopausal women",
abstract = "In both the rodent and primate, administration of progesterone elicits an acute surge-like release of LH in the setting of prior estrogen treatment. Whether these facilitative effects of estrogen and progesterone on gonadotropin secretion reside at pituitary or hypothalamic loci is not known. To further investigate the mechanisms by which estrogen comblined with progesterone amplifies gonadotropin secretion, we studied the responses of seven estrogen-primed postmenopausal women to progesterone administration with or without cotreatment with a potent GnRH antagonist, [Ac-D2Nal1,D4ClPhe2,D3Pal3,Arg 5,DGlu6(AA), DAla10]GnRH. Repetitive blood sampling for the later measurement of serum concentrations of LH, FSH, and PRL was begun 4 h before the administration of progesterone and continued for 36 h. We observed that progesterone administration after 72 h of priming with ethinyl estradiol resulted in a surge-like release of LH and FSH in all subjects. Concommitant administration of the GnRH antagonist abolished the surge-like release of both gonadotropins in all subjects. In contrast, administration of the antagonist had no effect on PRL release. These results indicate that endogenous GnRH action is an obligatory component of the progesterone-induced surge-like release of both gonado-tropic hormones in the estrogen-primed human.",
author = "Kolp, {Lisa A.} and Pavlou, {Spyros N.} and Urban, {Randall J.} and Rivier, {Jean C.} and Vale, {Wylie W.} and Veldhuis, {Johannes D}",
year = "1992",
language = "English (US)",
volume = "75",
pages = "993--997",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "4",

}

TY - JOUR

T1 - Abrogation by a potent gonadotropin-releasing hormone antagonist of the estrogen/progesteronestimulated surge-like release of luteinizing hormone and follicle-stimulating hormone in postmenopausal women

AU - Kolp, Lisa A.

AU - Pavlou, Spyros N.

AU - Urban, Randall J.

AU - Rivier, Jean C.

AU - Vale, Wylie W.

AU - Veldhuis, Johannes D

PY - 1992

Y1 - 1992

N2 - In both the rodent and primate, administration of progesterone elicits an acute surge-like release of LH in the setting of prior estrogen treatment. Whether these facilitative effects of estrogen and progesterone on gonadotropin secretion reside at pituitary or hypothalamic loci is not known. To further investigate the mechanisms by which estrogen comblined with progesterone amplifies gonadotropin secretion, we studied the responses of seven estrogen-primed postmenopausal women to progesterone administration with or without cotreatment with a potent GnRH antagonist, [Ac-D2Nal1,D4ClPhe2,D3Pal3,Arg 5,DGlu6(AA), DAla10]GnRH. Repetitive blood sampling for the later measurement of serum concentrations of LH, FSH, and PRL was begun 4 h before the administration of progesterone and continued for 36 h. We observed that progesterone administration after 72 h of priming with ethinyl estradiol resulted in a surge-like release of LH and FSH in all subjects. Concommitant administration of the GnRH antagonist abolished the surge-like release of both gonadotropins in all subjects. In contrast, administration of the antagonist had no effect on PRL release. These results indicate that endogenous GnRH action is an obligatory component of the progesterone-induced surge-like release of both gonado-tropic hormones in the estrogen-primed human.

AB - In both the rodent and primate, administration of progesterone elicits an acute surge-like release of LH in the setting of prior estrogen treatment. Whether these facilitative effects of estrogen and progesterone on gonadotropin secretion reside at pituitary or hypothalamic loci is not known. To further investigate the mechanisms by which estrogen comblined with progesterone amplifies gonadotropin secretion, we studied the responses of seven estrogen-primed postmenopausal women to progesterone administration with or without cotreatment with a potent GnRH antagonist, [Ac-D2Nal1,D4ClPhe2,D3Pal3,Arg 5,DGlu6(AA), DAla10]GnRH. Repetitive blood sampling for the later measurement of serum concentrations of LH, FSH, and PRL was begun 4 h before the administration of progesterone and continued for 36 h. We observed that progesterone administration after 72 h of priming with ethinyl estradiol resulted in a surge-like release of LH and FSH in all subjects. Concommitant administration of the GnRH antagonist abolished the surge-like release of both gonadotropins in all subjects. In contrast, administration of the antagonist had no effect on PRL release. These results indicate that endogenous GnRH action is an obligatory component of the progesterone-induced surge-like release of both gonado-tropic hormones in the estrogen-primed human.

UR - http://www.scopus.com/inward/record.url?scp=0026702302&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026702302&partnerID=8YFLogxK

M3 - Article

C2 - 1400893

AN - SCOPUS:0026702302

VL - 75

SP - 993

EP - 997

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 4

ER -