About a snail, a toad, and rodents: Animal models for adaptation research

Eric W. Roubos, Bruce G. Jenks, Lu Xu, Miyuki Kuribara, Wim J.J.M. Scheenen, Tamás Kozicz

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Neural adaptation mechanisms have many similarities throughout the animal kingdom, enabling to study fundamentals of human adaptation in selected animal models with experimental approaches that are impossible to apply in man. This will be illustrated by reviewing research on three of such animal models, viz. (1) the egg-laying behavior of a snail, Lymnaea stagnalis: how one neuron type controls behavior, (2) adaptation to the ambient light condition by a toad, Xenopus laevis: how a neuroendocrine cell integrates complex external and neural inputs, and (3) stress, feeding, and depression in rodents: how a neuronal network co-ordinates different but related complex behaviors. Special attention is being paid to the actions of neurochemical messengers, such as neuropeptide Y, urocortin 1, and brain-derived neurotrophic factor. While awaiting new technological developments to study the living human brain at the cellular and molecular levels, continuing progress in the insight in the functioning of human adaptation mechanisms may be expected from neuroendocrine research using invertebrate and vertebrate animal models.

Original languageEnglish (US)
Article numberArticle 4
JournalFrontiers in Endocrinology
Volume1
Issue numberOCT
DOIs
StatePublished - 2010

Keywords

  • Adaptation
  • Neurosecretion
  • Non-synaptic communication
  • Synaptic plasticity
  • Urocortin 1
  • αMsh

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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    Roubos, E. W., Jenks, B. G., Xu, L., Kuribara, M., Scheenen, W. J. J. M., & Kozicz, T. (2010). About a snail, a toad, and rodents: Animal models for adaptation research. Frontiers in Endocrinology, 1(OCT), [Article 4]. https://doi.org/10.3389/fendo.2010.00004