About a snail, a toad, and rodents: Animal models for adaptation research

Eric W. Roubos, Bruce G. Jenks, Lu Xu, Miyuki Kuribara, Wim J.J.M. Scheenen, Tamas Kozicz

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Neural adaptation mechanisms have many similarities throughout the animal kingdom, enabling to study fundamentals of human adaptation in selected animal models with experimental approaches that are impossible to apply in man. This will be illustrated by reviewing research on three of such animal models, viz. (1) the egg-laying behavior of a snail, Lymnaea stagnalis: how one neuron type controls behavior, (2) adaptation to the ambient light condition by a toad, Xenopus laevis: how a neuroendocrine cell integrates complex external and neural inputs, and (3) stress, feeding, and depression in rodents: how a neuronal network co-ordinates different but related complex behaviors. Special attention is being paid to the actions of neurochemical messengers, such as neuropeptide Y, urocortin 1, and brain-derived neurotrophic factor. While awaiting new technological developments to study the living human brain at the cellular and molecular levels, continuing progress in the insight in the functioning of human adaptation mechanisms may be expected from neuroendocrine research using invertebrate and vertebrate animal models.

Original languageEnglish (US)
Article numberArticle 4
JournalFrontiers in Endocrinology
Volume1
Issue numberOCT
DOIs
StatePublished - Dec 1 2010
Externally publishedYes

Fingerprint

Snails
Anura
Rodentia
Animal Models
Urocortins
Research
Lymnaea
Neuroendocrine Cells
Behavior Control
Neuropeptide Y
Brain-Derived Neurotrophic Factor
Xenopus laevis
Invertebrates
Ovum
Vertebrates
Depression
Neurons
Light
Brain

Keywords

  • αMsh
  • Adaptation
  • Neurosecretion
  • Non-synaptic communication
  • Synaptic plasticity
  • Urocortin 1

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Roubos, E. W., Jenks, B. G., Xu, L., Kuribara, M., Scheenen, W. J. J. M., & Kozicz, T. (2010). About a snail, a toad, and rodents: Animal models for adaptation research. Frontiers in Endocrinology, 1(OCT), [Article 4]. https://doi.org/10.3389/fendo.2010.00004

About a snail, a toad, and rodents : Animal models for adaptation research. / Roubos, Eric W.; Jenks, Bruce G.; Xu, Lu; Kuribara, Miyuki; Scheenen, Wim J.J.M.; Kozicz, Tamas.

In: Frontiers in Endocrinology, Vol. 1, No. OCT, Article 4, 01.12.2010.

Research output: Contribution to journalReview article

Roubos, Eric W. ; Jenks, Bruce G. ; Xu, Lu ; Kuribara, Miyuki ; Scheenen, Wim J.J.M. ; Kozicz, Tamas. / About a snail, a toad, and rodents : Animal models for adaptation research. In: Frontiers in Endocrinology. 2010 ; Vol. 1, No. OCT.
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