ABO blood group is associated with peripheral arterial disease in African Americans

The Multi-Ethnic Study of Atherosclerosis (MESA)

Mindy M. Pike, Nicholas Larson, Christina L. Wassel, Kevin P. Cohoon, Michael Y. Tsai, James S. Pankow, Naomi Q. Hanson, Paul A. Decker, Cecilia Berardi, Kristine S. Alexander, Mary Cushman, Neil A. Zakai, Suzette J Bielinski

Research output: Contribution to journalArticle

Abstract

Introduction Peripheral artery disease (PAD) affects 8.5 million Americans and thus improving our understanding of PAD is critical to developing strategies to reduce disease burden. The objective of the study was to determine the association of ABO blood type with ankle brachial index (ABI) as well as prevalent and incident PAD in a multi-ethnic cohort. Methods The Multi-Ethnic Study of Atherosclerosis includes non-Hispanic White, African, Hispanic, and Chinese Americans aged 45–84. ABO blood type was estimated using ABO genotypes in 6027 participants who had ABI assessed at the baseline exam. Associations with ABO blood type were evaluated categorically and under an additive genetic model by number of major ABO alleles. After excluding those with ABI > 1.4, prevalent PAD was defined as ABI ≤ 0.9 at baseline and incident PAD as ABI ≤ 0.9 for 5137 participants eligible for analysis. Results There were 222 prevalent cases and 239 incident cases of PAD. In African Americans, each additional copy of the A allele was associated with a 0.02 lower baseline ABI (p = 0.006). Each copy of the A allele also corresponded to 1.57-fold greater odds of prevalent PAD (95% CI, 1.17–2.35; p = 0.004), but was not associated with incident PAD. No associations were found in other racial/ethnic groups for ABI, prevalent PAD, or incident PAD across all races/ethnicities. Conclusions Blood type A and the A allele count were significantly associated with baseline ABI and prevalent PAD in African Americans. Further research is needed to confirm and study the mechanisms of this association in African Americans.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalThrombosis Research
Volume153
DOIs
StatePublished - May 1 2017

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Peripheral Arterial Disease
Blood Group Antigens
African Americans
Atherosclerosis
Ankle Brachial Index
Alleles
Asian Americans
Genetic Models
Hispanic Americans
Ethnic Groups
Genotype

Keywords

  • ABO blood group
  • Ankle brachial index
  • Atherosclerosis
  • Epidemiology
  • Peripheral arterial disease

ASJC Scopus subject areas

  • Hematology

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ABO blood group is associated with peripheral arterial disease in African Americans : The Multi-Ethnic Study of Atherosclerosis (MESA). / Pike, Mindy M.; Larson, Nicholas; Wassel, Christina L.; Cohoon, Kevin P.; Tsai, Michael Y.; Pankow, James S.; Hanson, Naomi Q.; Decker, Paul A.; Berardi, Cecilia; Alexander, Kristine S.; Cushman, Mary; Zakai, Neil A.; Bielinski, Suzette J.

In: Thrombosis Research, Vol. 153, 01.05.2017, p. 1-6.

Research output: Contribution to journalArticle

Pike, MM, Larson, N, Wassel, CL, Cohoon, KP, Tsai, MY, Pankow, JS, Hanson, NQ, Decker, PA, Berardi, C, Alexander, KS, Cushman, M, Zakai, NA & Bielinski, SJ 2017, 'ABO blood group is associated with peripheral arterial disease in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA)', Thrombosis Research, vol. 153, pp. 1-6. https://doi.org/10.1016/j.thromres.2017.02.018
Pike, Mindy M. ; Larson, Nicholas ; Wassel, Christina L. ; Cohoon, Kevin P. ; Tsai, Michael Y. ; Pankow, James S. ; Hanson, Naomi Q. ; Decker, Paul A. ; Berardi, Cecilia ; Alexander, Kristine S. ; Cushman, Mary ; Zakai, Neil A. ; Bielinski, Suzette J. / ABO blood group is associated with peripheral arterial disease in African Americans : The Multi-Ethnic Study of Atherosclerosis (MESA). In: Thrombosis Research. 2017 ; Vol. 153. pp. 1-6.
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abstract = "Introduction Peripheral artery disease (PAD) affects 8.5 million Americans and thus improving our understanding of PAD is critical to developing strategies to reduce disease burden. The objective of the study was to determine the association of ABO blood type with ankle brachial index (ABI) as well as prevalent and incident PAD in a multi-ethnic cohort. Methods The Multi-Ethnic Study of Atherosclerosis includes non-Hispanic White, African, Hispanic, and Chinese Americans aged 45–84. ABO blood type was estimated using ABO genotypes in 6027 participants who had ABI assessed at the baseline exam. Associations with ABO blood type were evaluated categorically and under an additive genetic model by number of major ABO alleles. After excluding those with ABI > 1.4, prevalent PAD was defined as ABI ≤ 0.9 at baseline and incident PAD as ABI ≤ 0.9 for 5137 participants eligible for analysis. Results There were 222 prevalent cases and 239 incident cases of PAD. In African Americans, each additional copy of the A allele was associated with a 0.02 lower baseline ABI (p = 0.006). Each copy of the A allele also corresponded to 1.57-fold greater odds of prevalent PAD (95{\%} CI, 1.17–2.35; p = 0.004), but was not associated with incident PAD. No associations were found in other racial/ethnic groups for ABI, prevalent PAD, or incident PAD across all races/ethnicities. Conclusions Blood type A and the A allele count were significantly associated with baseline ABI and prevalent PAD in African Americans. Further research is needed to confirm and study the mechanisms of this association in African Americans.",
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T1 - ABO blood group is associated with peripheral arterial disease in African Americans

T2 - The Multi-Ethnic Study of Atherosclerosis (MESA)

AU - Pike, Mindy M.

AU - Larson, Nicholas

AU - Wassel, Christina L.

AU - Cohoon, Kevin P.

AU - Tsai, Michael Y.

AU - Pankow, James S.

AU - Hanson, Naomi Q.

AU - Decker, Paul A.

AU - Berardi, Cecilia

AU - Alexander, Kristine S.

AU - Cushman, Mary

AU - Zakai, Neil A.

AU - Bielinski, Suzette J

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Introduction Peripheral artery disease (PAD) affects 8.5 million Americans and thus improving our understanding of PAD is critical to developing strategies to reduce disease burden. The objective of the study was to determine the association of ABO blood type with ankle brachial index (ABI) as well as prevalent and incident PAD in a multi-ethnic cohort. Methods The Multi-Ethnic Study of Atherosclerosis includes non-Hispanic White, African, Hispanic, and Chinese Americans aged 45–84. ABO blood type was estimated using ABO genotypes in 6027 participants who had ABI assessed at the baseline exam. Associations with ABO blood type were evaluated categorically and under an additive genetic model by number of major ABO alleles. After excluding those with ABI > 1.4, prevalent PAD was defined as ABI ≤ 0.9 at baseline and incident PAD as ABI ≤ 0.9 for 5137 participants eligible for analysis. Results There were 222 prevalent cases and 239 incident cases of PAD. In African Americans, each additional copy of the A allele was associated with a 0.02 lower baseline ABI (p = 0.006). Each copy of the A allele also corresponded to 1.57-fold greater odds of prevalent PAD (95% CI, 1.17–2.35; p = 0.004), but was not associated with incident PAD. No associations were found in other racial/ethnic groups for ABI, prevalent PAD, or incident PAD across all races/ethnicities. Conclusions Blood type A and the A allele count were significantly associated with baseline ABI and prevalent PAD in African Americans. Further research is needed to confirm and study the mechanisms of this association in African Americans.

AB - Introduction Peripheral artery disease (PAD) affects 8.5 million Americans and thus improving our understanding of PAD is critical to developing strategies to reduce disease burden. The objective of the study was to determine the association of ABO blood type with ankle brachial index (ABI) as well as prevalent and incident PAD in a multi-ethnic cohort. Methods The Multi-Ethnic Study of Atherosclerosis includes non-Hispanic White, African, Hispanic, and Chinese Americans aged 45–84. ABO blood type was estimated using ABO genotypes in 6027 participants who had ABI assessed at the baseline exam. Associations with ABO blood type were evaluated categorically and under an additive genetic model by number of major ABO alleles. After excluding those with ABI > 1.4, prevalent PAD was defined as ABI ≤ 0.9 at baseline and incident PAD as ABI ≤ 0.9 for 5137 participants eligible for analysis. Results There were 222 prevalent cases and 239 incident cases of PAD. In African Americans, each additional copy of the A allele was associated with a 0.02 lower baseline ABI (p = 0.006). Each copy of the A allele also corresponded to 1.57-fold greater odds of prevalent PAD (95% CI, 1.17–2.35; p = 0.004), but was not associated with incident PAD. No associations were found in other racial/ethnic groups for ABI, prevalent PAD, or incident PAD across all races/ethnicities. Conclusions Blood type A and the A allele count were significantly associated with baseline ABI and prevalent PAD in African Americans. Further research is needed to confirm and study the mechanisms of this association in African Americans.

KW - ABO blood group

KW - Ankle brachial index

KW - Atherosclerosis

KW - Epidemiology

KW - Peripheral arterial disease

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