Abnormalities of the vitamin D receptor in uraemia

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) receptor mediates many of the actions of 1,25(OH)2D3 in cells of target tissues. Abnormalities in vitamin D receptor concentration and regulation exist in tissues of subjects with chronic renal failure and end-stage renal disease. There is evidence that inhibitors of vitamin D receptor-1,25(OH)2D3 binding and 1,25(OH)2D3 action are present in dialysates and sera of individuals with end-stage renal disease. The biological significance of decreased vitamin D receptor number and altered vitamin D receptor regulation in uraemia is unclear at present as responses to 1,25(OH)2D3 in uraemia have not been systematically compared with responses in normal subjects.

Original languageEnglish (US)
Pages (from-to)6-10
Number of pages5
JournalNephrology Dialysis Transplantation
Volume11
Issue numberSUPPL. 3
DOIs
StatePublished - 1996

Keywords

  • 1,25(OH)D
  • Calcitrol
  • Calcium
  • Vitamin D receptor

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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