Abstract
The 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) receptor mediates many of the actions of 1,25(OH)2D3 in cells of target tissues. Abnormalities in vitamin D receptor concentration and regulation exist in tissues of subjects with chronic renal failure and end-stage renal disease. There is evidence that inhibitors of vitamin D receptor-1,25(OH)2D3 binding and 1,25(OH)2D3 action are present in dialysates and sera of individuals with end-stage renal disease. The biological significance of decreased vitamin D receptor number and altered vitamin D receptor regulation in uraemia is unclear at present as responses to 1,25(OH)2D3 in uraemia have not been systematically compared with responses in normal subjects.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6-10 |
| Number of pages | 5 |
| Journal | Nephrology Dialysis Transplantation |
| Volume | 11 |
| Issue number | SUPPL. 3 |
| DOIs | |
| State | Published - 1996 |
Keywords
- 1,25(OH)D
- Calcitrol
- Calcium
- Vitamin D receptor
ASJC Scopus subject areas
- Nephrology
- Transplantation
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Kumar, R. (1996). Abnormalities of the vitamin D receptor in uraemia. Nephrology Dialysis Transplantation, 11(SUPPL. 3), 6-10. https://doi.org/10.1093/ndt/11.supp3.6