TY - JOUR
T1 - Abnormalities of the vitamin D receptor in uraemia
AU - Kumar, R.
PY - 1996
Y1 - 1996
N2 - The 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) receptor mediates many of the actions of 1,25(OH)2D3 in cells of target tissues. Abnormalities in vitamin D receptor concentration and regulation exist in tissues of subjects with chronic renal failure and end-stage renal disease. There is evidence that inhibitors of vitamin D receptor-1,25(OH)2D3 binding and 1,25(OH)2D3 action are present in dialysates and sera of individuals with end-stage renal disease. The biological significance of decreased vitamin D receptor number and altered vitamin D receptor regulation in uraemia is unclear at present as responses to 1,25(OH)2D3 in uraemia have not been systematically compared with responses in normal subjects.
AB - The 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) receptor mediates many of the actions of 1,25(OH)2D3 in cells of target tissues. Abnormalities in vitamin D receptor concentration and regulation exist in tissues of subjects with chronic renal failure and end-stage renal disease. There is evidence that inhibitors of vitamin D receptor-1,25(OH)2D3 binding and 1,25(OH)2D3 action are present in dialysates and sera of individuals with end-stage renal disease. The biological significance of decreased vitamin D receptor number and altered vitamin D receptor regulation in uraemia is unclear at present as responses to 1,25(OH)2D3 in uraemia have not been systematically compared with responses in normal subjects.
KW - 1,25(OH)D
KW - Calcitrol
KW - Calcium
KW - Vitamin D receptor
UR - http://www.scopus.com/inward/record.url?scp=0029781176&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029781176&partnerID=8YFLogxK
U2 - 10.1093/ndt/11.supp3.6
DO - 10.1093/ndt/11.supp3.6
M3 - Article
C2 - 8840304
AN - SCOPUS:0029781176
VL - 11
SP - 6
EP - 10
JO - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
JF - Proceedings of the European Dialysis and Transplant Association - European Renal Association. European Dialysis and Transplant Association - European Renal Association. Congress
SN - 0931-0509
IS - SUPPL. 3
ER -