Abstract
The 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) receptor mediates many of the actions of 1,25(OH)2D3 in cells of target tissues. Abnormalities in vitamin D receptor concentration and regulation exist in tissues of subjects with chronic renal failure and end-stage renal disease. There is evidence that inhibitors of vitamin D receptor-1,25(OH)2D3 binding and 1,25(OH)2D3 action are present in dialysates and sera of individuals with end-stage renal disease. The biological significance of decreased vitamin D receptor number and altered vitamin D receptor regulation in uraemia is unclear at present as responses to 1,25(OH)2D3 in uraemia have not been systematically compared with responses in normal subjects.
Original language | English (US) |
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Pages (from-to) | 6-10 |
Number of pages | 5 |
Journal | Nephrology Dialysis Transplantation |
Volume | 11 |
Issue number | SUPPL. 3 |
DOIs | |
State | Published - 1996 |
Keywords
- 1,25(OH)D
- Calcitrol
- Calcium
- Vitamin D receptor
ASJC Scopus subject areas
- Nephrology
- Transplantation