Abnormalities of endoneurial microvessels and sural nerve pathology in diabetic neuropathy

H. Yasuda, Peter J Dyck

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

We measured the cellular components of 290 endoneurial microvessels in sural nerve of 34 diabetics and of 185 microvessels from 23 healthy subjects. Numbers of endothelial nuclei, area of endothelium, and thickness of basement membrane were significantly greater in diabetics with neuropathy than in controls and were statistically associated with severity of neuropathologic abnormality of myelinated fibers. The range of lumen areas was greater in diabetics than in controls, suggesting capillary dilatation of some vessels. Microvessels had pericytic debris in 8.5% of vessels from diabetics and none in controls.

Original languageEnglish (US)
Pages (from-to)20-28
Number of pages9
JournalNeurology
Volume37
Issue number1
StatePublished - 1987

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Sural Nerve
Diabetic Neuropathies
Microvessels
Pathology
Basement Membrane
Endothelium
Dilatation
Healthy Volunteers

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Abnormalities of endoneurial microvessels and sural nerve pathology in diabetic neuropathy. / Yasuda, H.; Dyck, Peter J.

In: Neurology, Vol. 37, No. 1, 1987, p. 20-28.

Research output: Contribution to journalArticle

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