Abnormalities of axonal transport. Are they a cause of peripheral nerve disease?

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Abstract

Applications of pulse-labeling techniques to the study of axonal transport have provided new insights into certain types of peripheral nerve disease. In normal neurons, many of the newly synthesized proteins that are rapidly transported to distal parts of the cell eventually undergo a process of 'turnaround,' after which they are carried back to the cell bodies for degradation. This turnaround is selectively impaired in rat nerves early in the course of streptozotocin-induced diabetes and of experimental neuropathies induced by exposure to acrylamide, zinc pyridinethione, or p-bromophenylacetylurea. In the neuropathy of p-bromo-phenylacetylurea, depression of turnaround precedes the clinical signs of neurologic dysfunction, is later proportional to the severity of the disability, and may account for the characteristic accumulation of debris in preterminal axons.

Original languageEnglish (US)
Pages (from-to)707-714
Number of pages8
JournalMayo Clinic proceedings
Volume57
Issue number11
StatePublished - Dec 1 1982

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ASJC Scopus subject areas

  • Medicine(all)

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