TY - JOUR
T1 - Abnormal rapid eye movement sleep atonia control in chronic post-traumatic stress disorder
AU - Feemster, John C.
AU - Steele, Tyler A.
AU - Palermo, Kyle P.
AU - Ralston, Christy L.
AU - Tao, Yumeng
AU - Bauer, David A.
AU - Edgar, Liam
AU - Rivera, Sonia
AU - Walters-Smith, Maxwell
AU - Gossard, Thomas R.
AU - Teigen, Luke N.
AU - Timm, Paul C.
AU - Richardson, Jarrett W.
AU - Robert Auger, R.
AU - Kolla, Bhanuprakash
AU - McCarter, Stuart J.
AU - Boeve, Bradley F.
AU - Silber, Michael H.
AU - Louis, Erik K.St
N1 - Funding Information:
This publication was supported by NIH/NCRR/NCATS CCaTS Grant Number UL1 TR002377, and by NIH/NIA R34AG056639 (NAPS). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.
Publisher Copyright:
© 2021 The Author(s) 2021.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Study Objectives: Post-traumatic stress disorder (PTSD) and rapid eye movement (REM) sleep behavior disorder (RBD) share some common features including prominent nightmares and sleep disturbances. We aimed to comparatively analyze REM sleep without atonia (RSWA) between patients with chronic PTSD with and without dream enactment behavior (DEB), isolated RBD (iRBD), and controls. Methods: In this retrospective study, we comparatively analyzed 18 PTSD with DEB (PTSD+DEB), 18 PTSD without DEB, 15 iRBD, and 51 controls matched for age and sex. We reviewed medical records to determine PTSD clinical features and quantitatively analyzed RSWA. We used nonparametric analyses to compare clinical and polysomnographic features. Results: PTSD patients, both with and without DEB, had significantly higher RSWA than controls (all p <. 025, excepting submentalis phasic duration in PTSD+DEB). Most RSWA measures were also higher in PTSD+DEB than in PTSD without DEB patients (all p <. 025). Conclusions: PTSD patients have higher RSWA than controls, whether DEB is present or not, indicating that REM sleep atonia control is abnormal in chronic PTSD. Further prospective studies are needed to determine whether neurodegenerative risk and disease markers similar to RBD might occur in PTSD patients. Statement of Significance Post-traumatic stress disorder (PTSD) and isolated rapid eye movement (REM) sleep behavior disorder (iRBD) both have prominent nightmares and sleep disturbances. In this retrospective study, we comparatively analyzed REM sleep without atonia (RSWA) between chronic PTSD with and without dream enactment behavior (DEB), and iRBD patients and controls. PTSD patients had higher RSWA than controls, whether DEB was present or not. RSWA is abnormal in chronic PTSD. Further prospective studies are needed to determine whether neurodegenerative risk and disease markers may occur in PTSD patients.
AB - Study Objectives: Post-traumatic stress disorder (PTSD) and rapid eye movement (REM) sleep behavior disorder (RBD) share some common features including prominent nightmares and sleep disturbances. We aimed to comparatively analyze REM sleep without atonia (RSWA) between patients with chronic PTSD with and without dream enactment behavior (DEB), isolated RBD (iRBD), and controls. Methods: In this retrospective study, we comparatively analyzed 18 PTSD with DEB (PTSD+DEB), 18 PTSD without DEB, 15 iRBD, and 51 controls matched for age and sex. We reviewed medical records to determine PTSD clinical features and quantitatively analyzed RSWA. We used nonparametric analyses to compare clinical and polysomnographic features. Results: PTSD patients, both with and without DEB, had significantly higher RSWA than controls (all p <. 025, excepting submentalis phasic duration in PTSD+DEB). Most RSWA measures were also higher in PTSD+DEB than in PTSD without DEB patients (all p <. 025). Conclusions: PTSD patients have higher RSWA than controls, whether DEB is present or not, indicating that REM sleep atonia control is abnormal in chronic PTSD. Further prospective studies are needed to determine whether neurodegenerative risk and disease markers similar to RBD might occur in PTSD patients. Statement of Significance Post-traumatic stress disorder (PTSD) and isolated rapid eye movement (REM) sleep behavior disorder (iRBD) both have prominent nightmares and sleep disturbances. In this retrospective study, we comparatively analyzed REM sleep without atonia (RSWA) between chronic PTSD with and without dream enactment behavior (DEB), and iRBD patients and controls. PTSD patients had higher RSWA than controls, whether DEB was present or not. RSWA is abnormal in chronic PTSD. Further prospective studies are needed to determine whether neurodegenerative risk and disease markers may occur in PTSD patients.
KW - REM sleep behavior disorder
KW - REM sleep without atonia
KW - dream enactment behavior
KW - post-traumatic stress disorder
UR - http://www.scopus.com/inward/record.url?scp=85126000456&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85126000456&partnerID=8YFLogxK
U2 - 10.1093/sleep/zsab259
DO - 10.1093/sleep/zsab259
M3 - Article
C2 - 34958372
AN - SCOPUS:85126000456
SN - 0161-8105
VL - 45
JO - Sleep
JF - Sleep
IS - 3
M1 - zsab259
ER -