Abnormal Levels of Metal Micronutrients and Autism Spectrum Disorder: A Perspective Review

Supriya Behl, Sunil Mehta, Mukesh K. Pandey

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of the present review is to summarize the prevalence of abnormal levels of various metal micronutrients including copper (Cu), iron (Fe), magnesium (Mg), zinc (Zn), and selenium (Se) in Autism Spectrum Disorder (ASD) using hair, nail and serum samples. A correlation of selected abnormal metal ions with known neurodevelopmental processes using Gene Ontology (GO) term was also conducted. Data included in this review are derived from ASD clinical studies performed globally. Metal ion disparity data is also analyzed and discussed based on gender (Male/Female) to establish any gender dependent correlation. Finally, a rational perspective and possible path to better understand the role of metal micronutrients in ASD is suggested.

Original languageEnglish (US)
Article number586209
JournalFrontiers in Molecular Neuroscience
Volume13
DOIs
StatePublished - Dec 10 2020

Keywords

  • biometals
  • copper
  • iron
  • magnesium
  • metal micronutrients
  • selenium and autism spectrum disorder
  • zinc

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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