Abnormal intestinal motility in diabetics with the gastroparesis syndrome

MICHAEL CAMILLERI, JUAN‐R ‐R MALAGELADA

Research output: Contribution to journalArticlepeer-review

269 Scopus citations

Abstract

Abstract. Gastroparesis syndrome is a recognized complication of longstanding diabetes mellitus and is attributed to reduced gastric contractility due to ‘autovagotomy’. However, motor abnormalities associated with this syndrome may not be limited to the stomach. To test this hypothesis we have studied the fasting and fed manometric profiles of the proximal small intestine of fourteen patients with the clinical diagnosis of gastroparesis. Abnormal intestinal manometric patterns were observed in twelve out of the fourteen patients. In four patients there was reduced duodenojejunal phasic pressure activity, whereas in nine there were non‐propagated long bursts of powerful contractions. Furthermore, while the majority of patients (eleven out of fourteen) exhibited the expected reduction in antral pressure activity and gastric phase III, a small subgroup of three patients exhibited a peculiar continuous 3 min‐1 antral contractile activity. Our findings show that the small intestine is frequently affected in patients with diabetic gastroparesis, and that the motility disorder both in the stomach and the small bowel is not invariably of a ‘paretic’ type. The occurrence of incoordinated intestinal long bursts and continuous antral activity suggests that disturbed sympathetic innervation participates in the aetiopathogenesis of their upper‐gut dysfunction.

Original languageEnglish (US)
Pages (from-to)420-427
Number of pages8
JournalEuropean Journal of Clinical Investigation
Volume14
Issue number6
DOIs
StatePublished - Dec 1984

Keywords

  • Diabetes mellitus
  • autonomic neuropathy
  • gastroparesis
  • oesophagogastrointestinal motility

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Abnormal intestinal motility in diabetics with the gastroparesis syndrome'. Together they form a unique fingerprint.

Cite this